Results 51 to 60 of about 441 (127)

A hypothetical scenario of TSPyV LT-antigen interference in cell cycle regulation.

, 2014
An oversimplified cell-cycling scenario is shown that envisions the TSPyV LT-antigen involvement in regulation of pRB pathway activity. In a normal physiological condition, hypophosphorylated pRB is complexed with transcription factor E2F during early G1
Mariet C. W. Feltkamp (244842), Elena Pope (640809), Arlene S. Rosenberg (640808), Philip Fleckman (152280), Taylor Benoit (640810), Siamaque Kazem (640807), Richard C. Wang (252512), Els van der Meijden (244837)   +7 more
core   +1 more source

The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer

Frontiers in Microbiology, 2018
Approximately 15–20% of human cancer is related to infection, which renders them potentially preventable by antimicrobial or antiviral therapy. Human polyomaviruses (PyVs) are relevant in this regard, as illustrated by the involvement of Merkel cell ...
Els van der Meijden, Mariet Feltkamp
doaj   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin α‐dependent nuclear localization signals

Protein Science, Volume 33, Issue 2, February 2024.
Abstract Nucleocytoplasmic transport regulates the passage of proteins between the nucleus and cytoplasm. In the best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates transport through the nuclear pore complex.
Emily M. Cross, Nasim Akbari, Hanieh Ghassabian, Mikayla Hoad, Silvia Pavan, Daryl Ariawan, Camilla M. Donnelly, Enrico Lavezzo, Gayle F. Petersen, Jade K. Forwood, Gualtiero Alvisi   +10 more
wiley   +1 more source

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

Frontiers in Microbiology, 2018
Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic ...
Karin J. Purdie, Charlotte M. Proby, Hasan Rizvi, Heather Griffin, John Doorbar, Mary Sommerlad, Mariet C. Feltkamp, Els Van der Meijden, Gareth J. Inman, Andrew P. South, Irene M. Leigh, Catherine A. Harwood, Catherine A. Harwood   +12 more
doaj   +1 more source

Cell binding and PsV infection of TSPyV mutants.

, 2015
(A) Cell binding analysis of TSPyV wild type (WT) and mutant VP1 pentamers to HEK293 and SVGA cells by flow cytometry. VP1 pentamers were covalently thio-labelled using Alexa Fluor 488 C5 maleimide.
Bärbel S. Blaum (114952), Mariet C. W. Feltkamp (244842), Luisa J. Ströh (469044), Walter J. Atwood (469045), Aisling S. Dugan (603948), Gretchen V. Gee (786526), Thilo Stehle (114963)   +6 more
core   +1 more source

Cell surface glycans featuring terminal sialic acids promote TSPyV attachment and pseudovirus infection.

, 2015
(A) Binding of Alexa Fluor 488-conjugated TSPyV VP1 pentamers to mock (PBS) or with 1 U/ml Clostridium perfringens type V neuraminidase pre-treated cells was analysed by flow cytometry. 30,000 gated events were measured for each sample.
Bärbel S. Blaum (114952), Mariet C. W. Feltkamp (244842), Luisa J. Ströh (469044), Walter J. Atwood (469045), Aisling S. Dugan (603948), Gretchen V. Gee (786526), Thilo Stehle (114963)   +6 more
core   +1 more source

Conserved binding site for terminal Neu5Ac build up by the BC2-loop.

, 2015
Mapping amino acid differences between (A, C) TSPyV VP1 and OraPyV VP1 and (B, D) TSPyV, OraPyV and ApanPyV based on the TSPyV VP1-GM1 complex structure. Amino acid differences between the two or three closely related viruses are coloured according their
Bärbel S. Blaum (114952), Mariet C. W. Feltkamp (244842), Luisa J. Ströh (469044), Walter J. Atwood (469045), Aisling S. Dugan (603948), Gretchen V. Gee (786526), Thilo Stehle (114963)   +6 more
core   +1 more source

Resolution of painful trichodysplasia spinulosa with topical cidofovir: case report

Journal of Dermatological Treatment
Purpose: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals.
Kevin M. Burningham, Ritu N. Swali, Peter L. Rady, Anisha B. Patel, Stephen K. Tyring   +4 more
doaj   +1 more source

The trichodysplasia spinulosa-associated polyomavirus : discovery - prevalence - infection - expression [PDF]

, 2016
  In dit proefschrift wordt de ontdekking van een nieuw polyomavirus beschreven, trichodysplasia spinulosa-associated polyomavirus (TSPyV).
Meijden, P.Z. van der
core