Results 31 to 40 of about 59,427 (290)
Blood, 2019 Insights into immune TTP (iTTP) pathophysiology have led to novel targeted therapies. Immunomodulatory strategies target anti-ADAMTS13 antibodies. Of these, rituximab is effective in inducing responses in refractory/relapsed TTP, and increasing relapse ...
M. Mazepa, C. Masias, Shruti Chaturvedi
semanticscholar +1 more source
ADAMTS13, TTP and Beyond [PDF]
Hereditary Genetics, 2013 Copyright: © 2012 Zheng XL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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TTP: Tool for Tumor Progression [PDF]
, 2013 In this work we present a flexible tool for tumor progression, which simulates the evolutionary dynamics of cancer. Tumor progression implements a multi-type branching process where the key parameters are the fitness landscape, the mutation rate, and the average time of cell division.
Reiter, Johannes +3 more
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Nucleic Acids Research, 2016 RNA-binding proteins (RBPs) facilitate post-transcriptional control of eukaryotic gene expression at multiple levels. The RBP tristetraprolin (TTP/Zfp36) is a signal-induced phosphorylated anti-inflammatory protein guiding unstable mRNAs of pro ...
Christopher Tiedje +7 more
semanticscholar +1 more source
Science-Business eXchange, 2011 U.S. and Canadian researchers have shown that the generic drug N-acetylcysteine, which is sold over the counter for some uses, could potentially be repurposed to treat thrombotic thrombocytopenic purpura, a hematological disorder for which cumbersome plasma exchange therapy has been the standard of care for nearly two decades.
openaire +2 more sources
The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3
Journal of Immunology, 2019 Key Points MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP. TNF regulation by MK2/3 is not restricted to TTP phosphorylation at S52 and S178. The MK2/3/TTP signaling axis contributes to sepsis in vivo. Visual Abstract Tristetraprolin (TTP)
Natalia Ronkina +12 more
semanticscholar +1 more source
From Intelligence gathering to Cyber Threat Detection [PDF]
Romanian Intelligence Studies Review, 2023 Intelligence plays a key role in the detection and neutralisation of threat actors in cyberspace, particularly when dealing with advanced ones. However, the relationship between intelligence and the final detection capabilities is not well–defined in ...
Antonio VILLALON-HUERTA +2 more
doaj
Adjuvant low-dose rituximab and plasma exchange for acquired TTP.
Blood, 2019 TO THE EDITOR: The introduction of plasmapheresis with plasma exchange has increased survival in patients with thrombotic thrombocytopenic purpura (TTP) from
J. Zwicker +9 more
semanticscholar +1 more source
Bottom-quark effects in Higgs production at intermediate transverse momentum
Journal of High Energy Physics, 2018 We provide a precise description of the Higgs boson transverse momentum distribution including top and bottom quark contributions, that is valid for transverse momenta in the range m b ≲ p ⊥ ≲ m t , where m b and m t are the bottom and top quark masses.
Fabrizio Caola +5 more
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The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma
Cancers, 2019 Hepatic lipid deposition and inflammation represent risk factors for hepatocellular carcinoma (HCC). The mRNA-binding protein tristetraprolin (TTP, gene name ZFP36) has been suggested as a tumor suppressor in several malignancies, but it increases ...
Tarek Kröhler +14 more
semanticscholar +1 more source