Results 21 to 30 of about 856 (96)

Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons

Aging Cell, Volume 24, Issue 4, April 2025.
Reduced collagen on the epidermal apical surface drives selective aging in sensory neurons of Caenorhabditis elegans, leading to excessive dendritic branching and related functional deficits. An immunoglobulin superfamily protein in interneurons acts upstream of collagen genes to maintain dendritic homeostasis during aging, with a downstream ...
Meera M. Krishna, Swapnil G. Waghmare, Ariel L. Franitza, Emily C. Maccoux, Lezi E   +4 more
wiley   +1 more source

Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors

Cell Proliferation, Volume 58, Issue 4, April 2025.
A combination of Ascl1, Pou4f1 and Myt1l was identified to promote functional reprogramming of cochlear spiral ganglion neurons based on biochemical, electrophysiological and single‐cell transcriptomic analyses. Abstract Degeneration of the cochlear spiral ganglion neurons (SGNs) is one of the major causes of sensorineural hearing loss and ...
Yuhang Huang, Zhen Chen, Jiang Chen, Jingyue Liu, Cui Qiu, Qing Liu, Linqing Zhang, Guang‐Jie Zhu, Xiaofeng Ma, Shuohao Sun, Yun Stone Shi, Guoqiang Wan   +11 more
wiley   +1 more source

Piezoelectric Heterojunctions as Bacteria‐Killing Bone‐Regenerative Implants

Advanced Materials, Volume 37, Issue 1, January 8, 2025.
TiO2/Bi2WO6 piezoelectric heterojunctions with engineered oxygen vacancies, interfacial built‐in electric fields and piezoelectric properties are constructed as bone implants. The heterojunctions achieve highly efficient and dynamic antimicrobial functions through near infrared (NIR)‐triggered photothermal and photodynamic therapies.
Youzhun Fan, Jinxia Zhai, Zhengao Wang, Zhaoyi Yin, Haoyan Chen, Maofei Ran, Zurong Zhu, Yubin Ma, Chengyun Ning, Peng Yu, Chuanbin Mao   +10 more
wiley   +1 more source

Diversity of Alternaria‐derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain

Food Frontiers, Volume 6, Issue 1, Page 185-217, January 2025.
The Alternaria genus includes over 250 fungal species that contaminate crops and food with harmful mycotoxins, posing risks to plant, animal, and human health. This review discusses the classification, impact, and prevalence of Alternaria mycotoxins, their toxicodynamics and toxicokinetics, and highlights the need for regulations and preventive ...
Sarfaraz Hussain, Aqleem Abbas, Maratab Ali, Israt Jahan, Muhammad Jabran, Muhammad Afaq Ahmed, Zienab F. R. Ahmed, Xinhua Zhang   +7 more
wiley   +1 more source

A Non‐Invasive and DNA‐free Approach to Upregulate Mammalian Voltage‐Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation

Advanced Science, Volume 11, Issue 47, December 18, 2024.
A terahertz (THz) wave‐based technique is introduced to upregulate mammalian CaV channels and neuronal Ca2+ signaling. The technique, validated by diverse methods including the molecular dynamics simulations, electrophysiological studies, and Ca2+ imaging, demonstrates increased calcium influx and activation of key neuronal signaling pathways, offering
Yuankun Sun, Jinli Geng, Yu Fan, Yangmei Li, Yuan Zhong, Jing Cai, Xiaodong Liu, Shaomeng Wang, Yubin Gong, Chao Chang, Yaxiong Yang, Chunhai Fan   +11 more
wiley   +1 more source

miRNA interplay: Mechanisms and therapeutic interventions in cancer

MedComm – Oncology, Volume 3, Issue 4, December 2024.
By integrating RNA sequencing, CRISPR, bioinformatics, and computational models, we have deepened understanding of MicroRNA (miRNA) interactions. miRNAs regulated by ceRNAs are closely linked to cancer development. They are detectable in various samples and serve as biomarkers for cancer diagnosis, prognosis, and prediction.
Zehua Wang, Hangxuan Wang, Shuhan Zhou, Jiasheng Mao, Zhiqing Zhan, Shiwei Duan   +5 more
wiley   +1 more source

TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission

Advanced Science, Volume 11, Issue 44, November 26, 2024.
Sun et al. described how TRPC3/6 in primary sensory neurons get recruited via released bradykinin after peripheral inflammation, which in turn facilitates BDNF secretion from spinal nociceptor terminals and potentiates synaptic transmission and eventually contributes to mechanical pain hypersensitivity.
Zhi‐Chuan Sun, Wen‐Juan Han, Zhi‐Wei Dou, Na Lu, Xu Wang, Fu‐Dong Wang, Sui‐Bin Ma, Zhi‐Cheng Tian, Hang Xian, Wan‐Neng Liu, Ying‐Ying Liu, Wen‐Bin Wu, Wen‐Guang Chu, Huan Guo, Fei Wang, Hui Ding, Yuan‐Ying Liu, Hui‐Ren Tao, Marc Freichel, Lutz Birnbaumer, Zhen‐Zhen Li, Rou‐Gang Xie, Sheng‐Xi Wu, Ceng Luo   +23 more
wiley   +1 more source

Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging‐related diseases

Aging Cell, Volume 23, Issue 10, October 2024.
CD4+T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4+T cells, results in a series of changes in the CD4+T cells pool making it involved in immunosenescence. CD4+T cells subsets aging as a treatment focus, offering novel approaches for
Tingting Xia, Ying Zhou, Jiayao An, Zhi Cui, Xinqin Zhong, Tianyi Cui, Bin Lv, Xin Zhao, Xiumei Gao   +8 more
wiley   +1 more source

Xanthurenic acid: A role in brain intercellular signaling

Journal of Neurochemistry, Volume 168, Issue 9, Page 2303-2315, September 2024.
The two compounds are structural analogues and the level of XA is regulated by the activity of KMO producing the precursor 3‐hydroxykynurenine. XA accumulates in neurons, while KYNA is present in astrocytes. Unknown factors regulate the release of each of these compounds.
Michel Maitre, Omar Taleb, Hélène Jeltsch‐David, Christian Klein, Ayikoe‐Guy Mensah‐Nyagan   +4 more
wiley   +1 more source

Voltage‐Gated Ion Channels: Structure, Pharmacology and Photopharmacology

ChemPhysChem, Volume 25, Issue 16, August 19, 2024.
Azobenzene‐based molecular photoswitches are compounds capable of intracellular bind within the pocket of conventional drugs, mimicking the interactions at the site. They enable the optical control of action potential firing through an external stimulus: light.
Vito F. Palmisano, Nuria Anguita‐Ortiz, Shirin Faraji, Juan J. Nogueira   +3 more
wiley   +1 more source