Results 31 to 40 of about 1,749,861 (126)

Fluorescence characterization of clinically-important bacteria [PDF]

, 2013
Healthcare-associated infections (HCAI/HAI) represent a substantial threat to patient health during hospitalization and incur billions of dollars additional cost for subsequent treatment.
Jan-Peter Muller, Brody, James P, Roberts Tom A., Lewis R Dartnell, Dartnell, Lewis R., Muller, J-P., Muller, J.P., Tom A Roberts, Muller, JP, Moore, G, Roberts, T.A., Dartnell Lewis R., Ginny Moore, Moore, Ginny, Dartnell, LR, Ward, J.M., Muller Jan-Peter, Moore Ginny, Ward, John M., Moore, G., Ward John M., Roberts, Tom A., Ward, JM, Roberts, TA, Dartnell, L.R., John M Ward   +25 more
core   +2 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Biosensors for Biotoxins Detection and Monitoring

Advanced Sensor Research, Volume 5, Issue 6, June 2026.
This review examines state‐of‐the‐art biosensing platforms for biotoxin detection, including antibody‐, aptamer‐, CRISPR‐, nanopore‐, whole cells‐ and MIP‐based sensors. It highlights advances in ultra‐sensitive detection, real‐matrix validation in food and water, and multiplexed analysis, and discusses how the integration with machine learning ...
Alissa Agerova, Juan Francisco Bada Juarez, Matteo Dal Peraro   +2 more
wiley   +1 more source

Identification and Optimization Study of Lipase Producing Bacteria Isolated from Municipal Waste and Bio-deteriorated Waste [PDF]

, 2022
Bio-deteriorated waste is the leftover organic matter of unwanted raw food which if not handled properly or left for natural degradation can cause health issues. Microorganisms have the ability to biodegrade waste by secreting enzymes.
Arvindkumar Dungrechiya, Harshitkumar J. Savalia   +1 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

TTX-sensitive Na⁺ currents.

, 2018
A) Steps to different voltages (indicated) produced inward currents with at least two kinetically distinct components (2Ca solution, n = 6). The fast component was through voltage-gated Na+ channels as it was blocked by application of 1 μM TTX (n = 6 ...
Alexandra V. Ulyanova (5142920), Roman E. Shirokov (5142923)   +1 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, Volume 600, Issue 10, Page 1491-1518, May 2026.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

SEMI‐1, A Novel Neuronal Selenium‐Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans

BioFactors, Volume 52, Issue 3, May/June 2026.
SEMI‐1 is a selenium‐binding protein in C. elegans that, different from its paralog, SEMO‐1, and its human ortholog, SELENBP1, has no enzymatic activity as a methanethiol oxidase. It is expressed in AFD and BAG neurons only and affects nematode thermotaxis, stress resistance, and lifespan.
Weiye Gong, Karl Köhnlein, Josephine Priebs, Lara Biegel, Nadine Urban, Verena Alexia Ohse, David Guerrero‐Gómez, Priscila Yumi Tanaka Shibao, Janine Kirstein, Anna Patricia Kipp, Holger Steinbrenner, Antonio Miranda‐Vizuete, Martin Srayko, Lars‐Oliver Klotz   +13 more
wiley   +1 more source

Elucidating the Origin of Tetrodotoxin in Pleurobranchaea maculata and Stylochoplana sp. [PDF]

, 2015
Tetrodotoxin (TTX) is an extremely potent neurotoxin that acts by selectively targeting voltage gated sodium channels blocking propagation of action potentials.
Salvitti, Lauren R.
core