Results 21 to 30 of about 1,749,861 (126)

New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism

Marine Drugs, 2018
The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with ...
Andrew D. Turner, David Fenwick, Andy Powell, Monika Dhanji-Rapkova, Charlotte Ford, Robert G. Hatfield, Andres Santos, Jaime Martinez-Urtaza, Tim P. Bean, Craig Baker-Austin, Paul Stebbing   +10 more
doaj   +1 more source

High colonization rates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli [PDF]

, 2014
BACKGROUND International travel contributes to the worldwide spread of multidrug resistant Gram-negative bacteria. Rates of travel-related faecal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae vary for different ...
Battegay, Manuel, Widmer, Andreas F., Andreas Neumayr, Frei, Reno, Neumayr, Andreas, Hatz, Christoph, Jaeger, Veronika K., Veronika K Jaeger, Johannes Blum, Sabine Haller, Andreas F Widmer, Susan DeCrom, Blum, Johannes, Reno Frei, Furrer, Hansjakob, Endimiani, Andrea, Hansjakob Furrer, DeCrom, Susan, Jaeger, Veronika K, Haller, Sabine, Manuel Battegay, Andrea Endimiani, Esther Kuenzli, Widmer, Andreas F, Christoph Hatz, Kuenzli, Esther   +25 more
core   +3 more sources

Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning. [PDF]

Adv Sci (Weinh)
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Zhao H, Shi G, Qin R, Sun Y, Guo W, Shi R, Peng M, Yang J, Zhao J, Liu Q, Xiao J, Zhang K, Liu Q, Yang W, Liu H.   +14 more
europepmc   +2 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Toxic Takifugu pardalis eggs found in Takifugu niphobles gut: Implications for TTX accumulation in the pufferfish [PDF]

, 2015
Pufferfish (Takifugu spp.) possess a potent neurotoxin, tetrodotoxin (TTX). TTX has been detected in various organisms including food animals of pufferfish, and TTX-producing bacteria have been isolated from these animals.
Kozaki, Ao, Komori, Keitaro, Kawane, Mitsuo, Noguchi, Shunsuke, Sugita, Haruo, Itoi, Shiro, Tsunashima, Tadasuke   +6 more
core   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson, D. Edwards, Q. Vuong, I. Obara   +3 more
wiley   +1 more source

SCREENING OF SECONDARY METABOLITE-PRODUCING BACTERIA ASSOCIATED WITH CORALS USING 16S rDNA-BASED APPROACH [PDF]

, 2003
A total of 42 coral-associated bacteria were screened for their ability to produce secondary metabolites by using 16S rDNA-based approach. A specific oligonucleotides primer was used to amplify DNA non-ribosomal peptide synthetase (NRPS).
Sabdono, Agus, Karna Radjasa, Ocky
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, Volume 13, Issue 47, 24 August 2026.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source