Results 121 to 130 of about 29,634 (242)
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan +3 more
wiley +1 more source
, 2015 Pufferfish (Takifugu spp.) possess a potent neurotoxin, tetrodotoxin (TTX). TTX has been detected in various organisms including food animals of pufferfish, and TTX-producing bacteria have been isolated from these animals.
Kozaki, Ao +6 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first‐in‐human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single center, randomized, double‐blind, placebo controlled, single ascending dose (SAD) and FEstudy in healthy Chinese
Ying Yang +14 more
wiley +1 more source
, 1997 Gu, Xiang Q., Sulayman Dib-Hajj, Marco A. Rizzo, and Stephen G. Waxman. TTX-sensitive and -resistant Na+currents, and mRNA for the TTX-resistant rH1 channel, are expressed in B104 neuroblastoma cells. J. Neurophysiol. 77: 236–246, 1997.
Marco A. Rizzo +3 more
core +1 more source
The toxic mechanism and application of tetrodotoxin (TTX) [PDF]
Tetrodotoxin (TTX) is a powerful toxin related to nerve cells that is commonly discovered at loads of puffer fish, and working out the best way of cooking, whereas keeping the flavour but getting rid of the toxicity has challenged people for decades ...
Zhang Xiaonan, Xiaonan Zhang
core +1 more source
Brainstem Astrocytes Regulate Estrus‐Dependent Oscillations in Food Intake
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.DVC astrocytes regulate food intake and caloric balance via modulation of NMDA receptor‐mediated glutamatergic signaling to brainstem DMV motoneurons. In female rats, GFAP‐IR intensity and astrocyte morphological complexity increased during periods of high estrogen levels when food intake was decreased, and chemogenetic manipulation of DVC astrocytes ...
K. Selin Ozkaya +4 more
wiley +1 more source
Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves.
, 2001 Sensory neurones co-express voltage-gated sodium channels that mediate TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) currents, which may contribute to chronic pain after nerve injury.
Aitken, A +8 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4945-4967, 15 June 2026.Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura +3 more
wiley +1 more source
Síntesis de intermedios de la ttx
, 2010 [EN] The present invention relates to the synthesis of intermediates that can be used in TTX synthesis and to the preparation thereof.[ES] La presente invención se refiere a la síntesis de intermedios útiles en la sintesis de TTX, y a la preparación de ...
Benito-Arenas, Raúl +3 more
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Síntesis de intermedios de la TTX
, 2009 Síntesis de intermedios de la TTX. La invención proporciona intermedios útiles para la síntesis de TTX y análogos de la misma, así como procedimientos para la síntesis de los mismos.
Benito-Arenas, Raúl +4 more
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