Results 61 to 70 of about 29,634 (242)

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Tetrodotoxin – Distribution and Accumulation in Aquatic Organisms, and Cases of Human Intoxication

Marine Drugs, 2008
Many pufferfish of the family Tetraodontidae possess a potent neurotoxin, tetrodotoxin (TTX). In marine pufferfish species, toxicity is generally high in the liver and ovary, whereas in brackish water and freshwater species, toxicity is higher in the ...
Osamu Arakawa, Tamao Noguch
doaj  

Difference in Uptake of Tetrodotoxin and Saxitoxins into Liver Tissue Slices among Pufferfish, Boxfish and Porcupinefish

Marine Drugs, 2018
Although pufferfish of the family Tetraodontidae contain high levels of tetrodotoxin (TTX) mainly in the liver, some species of pufferfish, boxfish of the family Ostraciidae, and porcupinefish of the family Diodontidae do not.
Yuji Nagashima, Akira Ohta, Xianzhe Yin, Shoichiro Ishizaki, Takuya Matsumoto, Hiroyuki Doi, Toshiaki Ishibashi   +6 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Spinal Cord Astrocytes Display a Switch From TTX-Sensitive to TTX-Resistant Sodium Currents After Injury-Induced Gliosis In Vitro

, 1998
MacFarlane, Stacey Nee and Harald Sontheimer. Spinal cord astrocytes display a switch from TTX-sensitive to TTX-resistant sodium currents after injury-induced gliosis in vitro. J. Neurophysiol. 79: 2222–2226, 1998. Two distinct morphological subtypes of
Stacey Nee Macfarlane, Harald Sontheimer
core   +1 more source

Distribution of Tetrodotoxin in the New Zealand Clam, Paphies australis, Established Using Immunohistochemistry and Liquid Chromatography-Tandem Quadrupole Mass Spectrometry

Toxins, 2018
Tetrodotoxin (TTX) is one of the most potent neurotoxins known. It was originally thought to only occur in puffer fish but has now been identified in twelve different classes of freshwater and marine organisms, including bivalves.
Laura Biessy, Kirsty F. Smith, Michael J. Boundy, Stephen C. Webb, Ian Hawes, Susanna A. Wood   +5 more
doaj   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Differentielle Interaktionen hochpotenter Lokalanästhetika mit TTX-sensitiven und TTX-resistenten Natriumströmen an Spinalganglienzellen der erwachsenen Ratte

, 2005
Spannungsabhängige TTX-resistente Natriumkanäle haben nach dem aktuellen Wissensstand eine große Bedeutung für die Schmerzempfindung. So beruhen chronische Schmerzsyndrome auf einer gesteigerten Expression und Aktivität dieser Kanäle.
Kerkmann, Heiko
core   +1 more source

Lactic acid bacteria reduce the toxicity of tetrodotoxin through peptidoglycan mediated binding

Aquaculture and Fisheries
Tetrodotoxin (TTX) is a potent neurotoxin found in nature, the possible presence of TTX in pufferfish ovaries, liver, and other processing waste poses a serious environmental and safety hazard.
Chang Liu, Jingqin Ye, Chang'e Wang, Hengliang Wang, Ying Lu   +4 more
doaj   +1 more source

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin

Toxins, 2019
Tetrodotoxin (TTX) is an extremely toxic marine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods or bivalves.
Paula Abal, M. Carmen Louzao, Natalia Vilariño, Mercedes R. Vieytes, Luis M. Botana   +4 more
doaj   +1 more source