Results 51 to 60 of about 29,634 (242)

Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes

, 2019
We tested whether tetrodotoxin (TTX) functions as a stress relieving substance in puffer fish. We orally administered TTX to the juveniles of hatchery-reared non-toxic tiger puffer Takifugu rubripes and measured the effects of TTX on brain corticotropin ...
Arakawa, Osamu, Sakakura, Yoshitaka, Takaoka, Minami, Takatani, Tomohiro, Amiya, Noriko, Amano, Masafumi, Sato, Haruka   +6 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current

Marine Drugs, 2011
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved.
Jaakko Haverinen, Minna Hassinen, Matti Vornanen   +2 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Tetrodotoxin-Producing Bacteria: Detection, Distribution and Migration of the Toxin in Aquatic Systems

Toxins, 2017
This review is devoted to the marine bacterial producers of tetrodotoxin (TTX), a potent non-protein neuroparalytic toxin. In addition to the issues of the ecology and distribution of TTX-producing bacteria, this review examines issues relating to toxin ...
Timur Yu. Magarlamov, Daria I. Melnikova, Alexey V. Chernyshev   +2 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Isolation of TTX-R and TTX-S I_Na Biophysical Properties.

, 2013
A. Boltzman curves for the voltage dependence of INa availability and conductance for the total cardiac INa (TTX-S + TTX-R INa; reproduction of the curve-fits from Figure 1C).
David S. Auerbach (470466), Kazuhiro Yamakawa (179894), Jack M. Parent (358783), James Offord (470469), Ikuo Ogiwara (470470), Brittany C. Clawson (470468), Guy M. Lenk (218955), Lori L. Isom (470471), Julie Jones (470467), Miriam H. Meisler (200572)   +9 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Effect of TTX on LDCs.

, 2013
Spatiotemporal maps created from video recordings of motor patterns of the whole rat colon. All arrows indicate infusion of PBS into proximal colon. a. Control LDCs followed by addition of TTX, added 1 min before the start of panel b. b.
Yuanjie Yu (399879), Xiaohui Du (285285), Jan D. Huizinga (399887), Hong Liao (124443), Sifeng Chen (124155), Sheng Yin (399884), Kongling Li (399880), Xinghai Hu (399883), Qingmin Gao (399885), Hesheng Luo (285237), Lu Hong (399882), Ji-Hong Chen (399878), Xiangdong Yin (399886), Qian Zhang (49333), Longying Jiang (399881)   +14 more
core   +1 more source

New Vectors of TTX Analogues in the North Atlantic Coast: The Edible Crabs Afruca tangeri and Carcinus maenas

Marine Drugs, 2023
Tetrodotoxin (TTX) and its analogues are naturally occurring toxins historically responsible for human poisoning fatalities in Eastern Asia. It is typically linked to the consumption of pufferfish and, to a lesser extent, marine gastropods and crabs.
Sandra Lage, Felicitas ten Brink, Adelino V. M. Canário, José P. Da Silva   +3 more
doaj   +1 more source