Results 31 to 40 of about 29,634 (242)

Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats

The Journal of Headache and Pain, 2022
Background Growing evidence supports the important role of persistent sodium currents (INaP) in the neuronal excitability of various central neurons.
Michiko Nakamura, Il-Sung Jang
doaj   +1 more source

Distribution of Tetrodotoxin in Pacific Oysters (Crassostrea gigas)

Marine Drugs, 2021
A potent and heat-stable tetrodotoxin (TTX) has been found to accumulate in various marine bivalve species, including Pacific oysters (Crassostrea gigas), raising a food safety concern.
Monika Dhanji-Rapkova, Andrew D. Turner, Craig Baker-Austin, Jim F. Huggett, Jennifer M. Ritchie   +4 more
doaj   +1 more source

The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

eLife, 2020
Rough-skinned newts (Taricha granulosa) use tetrodotoxin (TTX) to block voltage-gated sodium (Nav) channels as a chemical defense against predation.
Patric M Vaelli, Kevin R Theis, Janet E Williams, Lauren A O'Connell, James A Foster, Heather L Eisthen   +5 more
doaj   +1 more source

La serpiente y el arco iris (1988): un modelo fisiopatológico por sobredosis de tetrodotoxina

Revista de Medicina y Cine / Journal of Medicine and Movies
La Serpiente y el Arco Iris (1988) de Wes Craven supone un modelo docente atractivo que combina la farmacología y las alteraciones fisiológicas en muchos sistemas funcionales. Basada en un hecho real, este clásico del terror convertido en una película de
Carmen Fernández-Martos, Nora Suleiman-Martos, José Luis Gómez-Urquiza, Isabel Prieto-Gómez, Manuel Ramírez-Sánchez, Ana Belén Segarra-Robles, Francisco García-Cózar, Germán Domínguez-Vías   +7 more
doaj   +1 more source

TTX-sensitive Na⁺ currents.

, 2018
A) Steps to different voltages (indicated) produced inward currents with at least two kinetically distinct components (2Ca solution, n = 6). The fast component was through voltage-gated Na+ channels as it was blocked by application of 1 μM TTX (n = 6 ...
Alexandra V. Ulyanova (5142920), Roman E. Shirokov (5142923)   +1 more
core   +1 more source

Structures of mu O-conotoxins from Conus marmoreus - Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons [PDF]

, 2004
The muO-conotoxins are an intriguing class of conotoxins targeting various voltage-dependent sodium channels and molluscan calcium channels. In the current study, we have shown MrVIA and MrVIB to be the first known peptidic inhibitors of the transient ...
Thomas, L., L. Daly, Norelle, Daly, NL, Craik, D. J., Adams, D. J., Adams, D.J., J. Craik, David, Ekberg, J.A., Ekberg, Jenny, Lewis, R. J., Lewis, RJ, Craik, D.J., Adams, Denise, Craik, DJ, Ekberg, JA, Adams, DJ, Lewis, R.J., J. Adams, David, Ekberg, J. A., J. Lewis, Richard, Daly, N. L., Daly, N., Thomas, Linda, Lewis, Richard J., A. Ekberg, Jenny, Thomas, L, Daly, Norelle L., Craik, David   +27 more
core   +1 more source

Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury

Molecular Pain, 2008
Voltage-gated sodium channels play important roles in modulating dorsal root ganglion (DRG) neuron hyperexcitability and hyperalgesia after peripheral nerve injury or inflammation.
Song Xue-Jun, Huang Zhi-Jiang
doaj   +1 more source

No evidence for a culturable bacterial tetrodotoxin producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida)

, 2015
Tetrodotoxin (TTX) is a potent neurotoxin found in the tissues of many taxonomically diverse organisms. Its origin has been the topic of much debate, with suggestions including endogenous production, acquisition through diet, and symbiotic bacterial ...
Salvitti, Lauren R., Susanna A. Wood, Paul McNabb, Lauren Salvitti, McNabb, Paul, Cary, S. Craig, Susanna Wood, Wood, Susanna A., Stephen Cary, Lauren R. Salvitti, Stephen Craig Cary   +10 more
core   +1 more source

Tetrodotoxins Secretion and Voltage-Gated Sodium Channel Adaptation in the Ribbon Worm Kulikovia alborostrata (Takakura, 1898) (Nemertea)

Toxins, 2021
Nemertea is a phylum of marine worms whose members bear various toxins, including tetrodotoxin (TTX) and its analogues. Despite the more than 30 years of studying TTXs in nemerteans, many questions regarding their functions and the mechanisms ensuring ...
Anna E. Vlasenko, Vasiliy G. Kuznetsov, Grigorii V. Malykin, Alexandra O. Pereverzeva, Peter V. Velansky, Konstantin V. Yakovlev, Timur Yu. Magarlamov   +6 more
doaj   +1 more source

Influence of Surface Finish on the Tribological Performance of AlTiBN Coatings Deposited on Forming Tools

Advanced Engineering Materials, EarlyView.
Aluminum and nitride coatings are used in industry because they are hard, resist wear, and protect against oxidation. Adding boron can improve friction behavior and other properties. This study tests coatings on surfaces with different finishes. Results show smoother surfaces perform better, while rough ones wear faster, although coatings can reduce ...
Adrián Claver, Iker Alfonso, Eneko Barba, Javier León, José Antonio García, Iñaki Zalakain, Iván Fernández Martínez, Arley García‐Carrero, Christian Almeyda, Daniel Salcedo   +9 more
wiley   +1 more source