Results 21 to 30 of about 29,634 (242)

An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer

Scientific Reports, 2022
Toxic puffers contain the potent neurotoxin, tetrodotoxin (TTX). Although TTX is considered to serve as a defense substance, previous behavioral studies have demonstrated that TTX acts as an attractive pheromone for some toxic puffers.
Yoshihisa Noguchi, Takehisa Suzuki, Keigo Matsutani, Ryo Sakakibara, Ryota Nakahigashi, Masaatsu Adachi, Toshio Nishikawa, Hideki Abe   +7 more
doaj   +1 more source

Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Toxins, 2021
Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels.
Rafael González-Cano, M. Carmen Ruiz-Cantero, Miriam Santos-Caballero, Carlos Gómez-Navas, Miguel Á. Tejada, Francisco R. Nieto   +5 more
doaj   +1 more source

Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes [PDF]

, 2020
Autoantibody signatures of circulating mucin fragments stem from cancer tissues, and microenvironments are promising biomarkers for cancer diagnosis and therapy.
Yokoi, Yasuhiro, Hinou, Hiroshi [0000-0003-2223-7300], Matsushita, Takahiko [0000-0001-9741-3722], Matsuoka, Koji, Nouso, Kazuhiro, Nishimura, Shin-Ichiro, Wakui, Hajime, Garcia-Martin, Fayna [0000-0001-9118-3874], Kamiyama, Toshiya, Taketomi, Akinobu, Hayakawa, Shun   +10 more
core   +1 more source

Transcriptome analysis revealed gene expression feminization of testis after exogenous tetrodotoxin administration in pufferfish Takifugu flavidus

BMC Genomics, 2022
Tetrodotoxin (TTX) is a deadly neurotoxin and usually accumulates in large amounts in the ovaries but is non-toxic or low toxic in the testis of pufferfish. The molecular mechanism underlying sexual dimorphism accumulation of TTX in ovary and testis, and
Xue He, Hexing Wu, Yaping Ye, Xiaolin Gong, Baolong Bao   +4 more
doaj   +1 more source

Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods [PDF]

, 2017
Tetrodotoxin (TTX) and its analogues are produced by marine bacteria and have been detected in marine bivalves and gastropods from European waters. The European Commission asked EFSA for a scientific opinion on the risks to public health related to the ...
Ceccatelli, S,, Edler, L, Brüschweiler, B, EFSA, Panel on Contaminants in the Food Chain (CONTAM), Knutsen, HK, Barregård, L, Bignami, M, Alexander, J, Cottrill, B, Dinovi, M   +9 more
core   +4 more sources

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells. [PDF]

J Physiol
Abstract figure legend Vibrodissociated Pukinje neurons retain active synaptic connections, including those from adhering fragments of the climbing fibre. These fragments generate excitatory synaptic events and the frequency of these events is increased by exposure to either NMDA [with d‐serine (d‐ser) as a co‐agonist] or glycine at a high (100 µM ...
Benton DCH, Robertson AD, Caldwell M, Pankratov Y, Imam L, Smart TG, Morris G, Moss GWJ.   +7 more
europepmc   +2 more sources

Antimicrobial activity of Tetrodotoxin extracted from liver, skin and muscles of puffer fish, Lagocephalus sceleratus inhabiting Mediterranean Sea, Egypt [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2017
Tetrodotoxin (TTX) is a strong marine toxin which is a powerful sodium channel inhibitor. So far, there is no known antidote for TTX to block its toxicity.
Ahmed Alabssawy
doaj   +1 more source

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

Toxins, 2018
Tetrodotoxin (TTX) is a marine biotoxin that has high scientific value. However, the lack of efficient TTX extraction and preparation methods has led to a scarcity of TTX samples for clinical application.
Xiaojun Zhang, Chengcheng Han, Si Chen, Le Li, Jingjing Zong, Junjie Zeng, Guangming Mei   +6 more
doaj   +1 more source

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
Sarah C. Finch, Michael J. Boundy, D. Tim Harwood   +2 more
doaj   +1 more source

Disrupted Vestibular Nuclei Neuron Development in a Chick Model for Congenital Vestibular Disorders. [PDF]

Dev Neurobiol
ABSTRACT Children with syndromic, congenital vestibular disorders (CVDs) form a sac‐like inner ear with missing or truncated semicircular canals and experience delayed motor development with lifelong challenges to maintain posture and balance. How the abnormal inner ear affects downstream central vestibular neural circuitry has not been investigated ...
Bogin EB, Conti R, Gallagher K, Oguz K, Popratiloff A, Peusner KD.   +5 more
europepmc   +2 more sources