Results 11 to 20 of about 29,634 (242)
Investigating Diet as the Source of Tetrodotoxin in Pleurobranchaea maculata
Marine Drugs, 2013 The origin of tetrodotoxin (TTX) is highly debated; researchers have postulated either an endogenous or exogenous source with the host accumulating TTX symbiotically or via food chain transmission.
Serena Khor +6 more
doaj +2 more sources
Intracellular Immunohistochemical Detection of Tetrodotoxin in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria) [PDF]
Marine Drugs, 2015 Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp ...
Lauren R. Salvitti +3 more
doaj +2 more sources
Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals
Marine Drugs, 2013 Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported.
Brett A. Neilan +3 more
doaj +2 more sources
Synthesis of ttx intermediates
, 2010 The present invention relates to the synthesis of intermediates which are useful in TTX synthesis and to the preparation thereof.
Noheda Marín, Pedro +4 more
openaire +3 more sources
An Updated Review of Tetrodotoxin and Its Peculiarities
Marine Drugs, 2022 Tetrodotoxin (TTX) is a crystalline, weakly basic, colorless organic substance and is one of the most potent marine toxins known. Although TTX was first isolated from pufferfish, it has been found in numerous other marine organisms and a few terrestrial ...
Panagiota Katikou +4 more
doaj +1 more source
Marine Drugs, 2020 A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora
Daria I. Melnikova +1 more
doaj +1 more source
Toxins, 2020 To investigate pufferfish accumulation, elimination, and distribution of tetrodotoxin (TTX), Takifugu obscurus was fed with wild TTX-containing gastropod Nassarius semiplicata to simulate the natural food chain. Three-month-old non-poisonous T.
Xiaojun Zhang +6 more
doaj +1 more source
TTX-S/TTX-R Na<sup>+</sup> Currents Coordinately Fine-Tune Depolarization/Firing Capability Revealed by Voltage Derivatives/Displacement Current Phase Plots With Dynamic Current-Clamp Simulation in Rat Visceral Sensory Neurons. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim To investigate how tetrodotoxin‐sensitive (TTX‐S) and tetrodotoxin‐resistant (TTX‐R) Na+ channels coordinately fine‐tune action potential (AP) depolarization and firing capability in rat nodose visceral sensory neurons. Methods APs were recorded by ruptured‐patch current clamp in unmyelinated C‐type and myelinated Ah‐type neurons from ...
Jing-Ran Z +6 more
europepmc +2 more sources
Toxins, 2023 The xanhid crab Atergatis floridus and the blue-lined octopus Hapalochlaena cf. fasciata have long been known as TTX-bearing organisms. It has been speculated that the TTX possessed by both organisms is exogenously toxic through the food chain, since ...
Yuchengmin Zhang +4 more
doaj +1 more source
International Journal of Biological Sciences, 2009 Persistent tetrodotoxin-resistant (TTX-R) Na+ (Nav1.9/SCN11A) currents are not normally recorded in vagal afferent neurons (VANs) with 50 mM of extracellular Na+ although the functional expression of this current was observed in the presence of PGE2 or ...
Guo-Fen Qiao, Bai-Yan Li, Yu-Hong Zhou, Yan-Jie Lu, John H. Schild
doaj +1 more source