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The Tuberous Sclerosis Complex Genes in Tumor Development

Cancer Investigation, 2004
The study of hereditary tumor syndromes has laid a solid foundation toward understanding the genetic basis of cancer. One of the latest examples comes from the study of tuberous sclerosis complex (TSC). As a member of the phakomatoses, TSC is characterized by the appearance of benign tumors, most notably in the central nervous system, kidney, heart ...
Baldwin C, Mak, Raymond S, Yeung
openaire   +2 more sources

Possible mechanisms of disease development in tuberous sclerosis

The Lancet Oncology, 2008
The two-hit hypothesis presented by Knudson in 1971 explains the development of tumours deficient in anti-oncogenes. Hamartomas in patients with tuberous sclerosis usually fit into this model, the first hit is a congenital lesion of either of the tuberous sclerosis genes (TSC1 or TSC2), and the second hit is loss of heterozygosity of this gene ...
Jaroslaw, Jozwiak   +2 more
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The respiration of developing potato tubers

European Potato Journal, 1964
The rate of O2-uptake and CO2-output, at 10°C., of tubers (var.Majestic) soon after they were formed at the end of June was about 50 ml/kg/hr, and fell during development to final values, before the death of the foliage, of the order of 4–5 ml/kg/hr. The quotient CO2/O2 remained within the range 0,85–1,19.
openaire   +1 more source

Development and growth of potato tubers in microgravity

Advances in Space Research, 1998
A potato explant consisting of a leaf, its axillary bud, and a small segment of stem will develop a tuber in 10-14 days when grown on earth. The tubers develop from the axillary buds and accumulate starch derived from sugars produced through photosynthesis and/or mobilized from leaf tissue.
M E, Cook   +5 more
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Mobile RNAs and proteins: Prospects in storage organ development of tuber and root crops.

Plant Science, 2019
Storage tuber and root crops make up a significant portion of the world's subsistence food supply. Because of their importance in food security, yield enhancement has become a priority.
Bhavani Natarajan   +3 more
semanticscholar   +1 more source

Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers

Acta Neuropathologica, 2002
The ERM (ezrin, radixin, and moesin) proteins belong to the band-4.1 superfamily of membrane-cytoskeleton-linking proteins which bind to the actin cytoskeleton via their C-terminal sequences and bind ERM binding membrane proteins (ERMBMPs). We investigated the immunohistochemical expression of two of the ERM proteins (ezrin and moesin) in developing ...
Michael W, Johnson   +2 more
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MicroRNAs Associated with Tuberous Root Development

2017
MicroRNAs (miRNAs) are a class of small noncoding RNAs that perform important regulatory roles in plant growth and development. In this chapter, we introduced the miRNAs associated with radish tuberous root development at the whole genome level. Five small RNA (sRNA) libraries were constructed from roots of Asian big radish at different developmental ...
Yuyan Sun, Xixiang Li
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Solanum tuberosum Agglutinin Accumulation during Tuber Development

Journal of Plant Physiology, 1991
Summary The deposition of potato lectin during tuber growth was studied using tissue printing and ELISA techniques. Lectin accumulation starts early during tuber formation. When the stolon shows the first signals of radial growth, immunologically detectable lectin appears in the cortex and pith regions.
Rafael F. Pont-Lezica   +2 more
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Yellow Nutsedge Tuber Germination and Seedling Development

Weed Science, 1972
Upon germination, one or more rhizomes grew from the apical end of each yellow nutsedge(Cyperus esculentusL.) tuber. Each rhizome developed a basal bulb upon exposure to light. No significant differences in germination percentages existed between four lots of tubers which differed about fivefold in weight.
E. W. Stoller, D. P. Nema, V. M. Bhan
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Development of the Stem Tuber in Kohlrabi

Journal of Experimental Botany, 1967
Stem swelling in kohlrabi (KR) normally occurred between the third and fifth node and followed initiation of meristematic activity in pith parenchyma cells ; this usually began about 7 weeks after germination and was associated with the death of parenchyma cells in the centre of the pith lower down the stem.
I. W. SELMAN, S. KULASEGARAM
openaire   +1 more source

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