Results 111 to 120 of about 61,970 (240)

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis

, 2012
BACKGROUND: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are
Ettehad, Dena, Schaaf H.S., Schaaf, H S, Ettehad, D, Ford, N, Ford, Nathan, Seddon, J A, Cooke, Graham S, Ettehad D., Ford N., Schaaf, H Simon, Seddon, James A, Cooke G.S., Cooke, G S, Seddon J.A.   +14 more
core   +1 more source

Social aspects multi-drug resistant tuberculosis

Бюллетень сибирской медицины, 2012
The comparative analysis of features of clinical symptoms, spectrum and the importance of burdening medico-social factors of a tuberculosis of lungs with primary MDR М.
O. V. Filinyuk, O. I. Urazova, Ye. V. Nekrasov, L. N. Buinova, O. V. Kolokolova, I. G. Felker, O. Yu. Khristenko   +6 more
doaj   +1 more source

Mycobacterium tuberculosis resistance to antituberculosis drugs in Mozambique

Jornal Brasileiro de Pneumologia, 2014
OBJECTIVE: To determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique. METHODS: We analyzed secondary data from the National Tuberculosis Referral Laboratory, in the city of Maputo, Mozambique, and from the Beira Regional ...
Germano Manuel Pires, Elena Folgosa, Ndlovu Nquobile, Sheba Gitta, Nureisha Cadir   +4 more
doaj   +1 more source

Mechanism‐Based Polypharmacy as a Repurposing Strategy: The Case of D‐Cycloserine and Lurasidone

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug–drug interactions. There is growing interest in and clinical acceptance of rational, mechanism‐based drug combinations that are designed around desirable pharmacological properties rather than trial and ...
Avery D. Franzen, John S. Svendsen, Cassidy J. Kline, Susan Q. Shen   +3 more
wiley   +1 more source

Hematological Profiles of Pulmonary Tuberculosis and Multi‐Drug‐Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North‐Central Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports
Background and Aims Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug‐resistant tuberculosis.
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, Mulat Erkihun, Ayenew Assefa, Birhanemaskal Malkamu, Getu Abeje, Birhanu Getie, Yenealem Solomon   +10 more
doaj   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in Tigray Region, Ethiopia: a case–control study

BMJ Open Respiratory Research
Background Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first-line antituberculosis drugs namely, rifampicin and isoniazid. However, most of these studies were limited only to a single hospital.
Kidane Zereabruk, Tensay Kahsay, Hiyab Teklemichael, Woldu Aberhe, Abrha Hailay, Guesh Mebrahtom, Gebrewahd Bezabh   +6 more
doaj   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Acute glomerulonephritis in a child with multidrug-resistant tuberculosis and multibacillary leprosy

, 2011
A 10-year-old boy from Papua New Guinea with multidrug-resistant tuberculosis and multibacillary leprosy developed acute glomerulonephritis while being treated as an inpatient at Thursday Island Hospital in the Torres Strait, Queensland.
Jones, Samuel P., Furlong, Timothy J., Parish, Shaun T., Kippin, Alexander N., McIver, Lachlan J.   +4 more
core