Results 21 to 30 of about 39,720 (193)

Diagnostic value of the combined test of leukocytes in urine and TB-DOT and T-SPOT.TB in blood for urinary tuberculosis

Frontiers in Microbiology
BackgroundThis study aims to evaluate the clinical utility of routine urinary tests and renal function assessments, as well as the Tuberculosis antibody test (TB-DOT) and T-cell spot tests for TB infection (T-SPOT.TB), either individually or in ...
Yanyan Li, Yanyan Li, Yanyan Li, Yanyan Li, Yanyan Li, Yachun Wang, Yachun Wang, Yachun Wang, Yachun Wang, Yachun Wang, Lukuan Wei, Lukuan Wei, Lukuan Wei, Lukuan Wei, Lukuan Wei, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang   +19 more
doaj   +1 more source

Emergence of drug resistance in patients with tuberculosis cared for by the Indian health-care system: a dynamic modelling study

The Lancet Public Health, 2017
Background: India has the highest number of patients with tuberculosis and multidrug-resistant tuberculosis in the world. We used a transmission model to project the emergence of drug resistance in India due to incorrect tuberculosis management practices
Stephanie Law, MSc, Amy S Piatek, MSc, Cheri Vincent, MSPH, Olivia Oxlade, PhD, Prof Dick Menzies, MD   +4 more
doaj   +1 more source

Transmission of multidrug-resistant tuberculosis

The Pediatric Infectious Disease Journal, 2000
To compare the Mycobacterium tuberculosis isolates of adult index cases with multidrug-resistant (MDR) tuberculosis to the isolates obtained from their child contacts.A 4-year prospective study in the Western Cape Province of South Africa. We evaluated 149 child contacts of 80 adult MDR pulmonary tuberculosis cases.
Schaaf H.S., Van Rie A., Gie R.P., Beyers N., Victor T.C., Van Helden P.D., Donald P.R.   +6 more
openaire   +4 more sources

Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study.

PLoS ONE, 2015
Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases.
Helen R Stagg, James Brown, Elmira Ibraim, Vija Riekstiņa, Piret Viiklepp, Andra Cīrule, Horia Cocei, Manfred Danilovitš, Gunta Dravniece, Charlotte Jackson, Peter J White   +10 more
doaj   +1 more source

Epidemic characteristics and drug resistance of tuberculosis in North China

Heliyon, 2020
To analyze the epidemiological characteristics and drug resistance of tuberculosis (TB) patients in northern China. The epidemiological characteristics of 620 patients with tuberculosis from 2014 to 2016 were analyzed, including gender, age, occupation ...
Zheng Qi, Xi Gao, Yan-fu Wang, Chang Liu
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Congenital Transmission of Multidrug-Resistant Tuberculosis [PDF]

The American Society of Tropical Medicine and Hygiene, 2014
This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB to the infant was suspected, because direct postpartum
Espiritu, Nora, Aguirre, Lino, Jave, Oswaldo, Sanchez, Luis, Kirwan, Daniela E., Gilman, Robert Hugh   +5 more
openaire   +2 more sources

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Prevalence and epidemic pattern of ecdemic multidrug-resistant tuberculosis during 2012–2022 in Hangzhou, China: implication for public health strategies

BMC Public Health
Background To assess the prevalence and epidemic pattern of multidrug-resistant tuberculosis in Hangzhou City, Zhejiang Province, China during 2012–2022.
Qingchun Li, Yifei Wu, Qinglin Cheng, Min Lu, Yinyan Huang, Xuexin Bai, Qingjun Jia, Zijian Fang, Liyun Ai, Nan Jiang, QiuFeng Lao, Li Xie, Junfang Chen   +12 more
doaj   +1 more source