Results 141 to 150 of about 975,760 (305)

Disease of South American camelids in England and Wales: Analysis of diagnoses from Animal and Plant Health Agency laboratory submissions between 2012 and 2021

Veterinary Record, EarlyView.
Abstract Background South American camelids (SACs) have become increasingly popular in the UK. Consequently, knowledge among veterinary practitioners about diseases in these non‐native species has improved, although gaps remain. The remit of this study was to identify common diseases of SACs based on Animal and Plant Health Agency (APHA) surveillance ...
Sonja Jeckel, Carissa Xian Chow, David Jorge   +2 more
wiley   +1 more source

Alterations in Nasal Function Following Total Laryngectomy and Their Clinical Correlates

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Although nasal structural and functional changes after total laryngectomy (TL) have been documented, the influence of clinical variables and symptoms remains underexplored. This study compared nasal structure and function between TL patients and healthy controls and identified clinical factors associated with these changes ...
Kajornpan Sermwittayawong, Paraya Assanasen, Phawin Keskool, Dichapong Kanjanawasee   +3 more
wiley   +1 more source

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis

Annals of Clinical Microbiology and Antimicrobials
Background While several recent studies have documented the importance of efflux pumps as mediators of rifampin (RIF) resistance, it remains uncertain which efflux pumps play major roles in rifampin-resistant Mycobacterium tuberculosis strains harboring ...
Fanrong Meng, Yuanjin Chen, Zeyou Wei, Zhihui Liu, Xiaomin Lai, Jie Lei, Ling Wu, Li Deng, Qi Wang, Yu Yang, Hua Li, Bei Xie, Lan Gong, Qun Niu, Junwen Gao, Nan Wang, Jinxing Hu   +16 more
doaj   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source

Bioequivalence and Safety of Two Amisulpride Formulations in Healthy Chinese Subjects Under Fasting and Fed Conditions: A Randomized, Open‑Label, Single‑Dose, Crossover Study

Drugs in R&D
Background and Objectives Amisulpride is a second-generation antipsychotic drug that selectively binds to D2 and D3 dopaminergic receptors in the limbic system.
Min Wang, Yu Peng, Hegui Yan, Zhixiang Pan, Ronghui Du, Guan Liu   +5 more
doaj   +1 more source

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

Allergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat   +18 more
wiley   +1 more source

Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival

Nature Communications
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) can promote their survival within infected cells by preventing lysosomal acidification. Here, we report that Mtb secretes a protein (Rv1184, or acyltransferase Chp2) that inhibits lysosomal
Jianxia Chen, Fen Tang, Lianhua Qin, Weijun Fang, Liru Guan, Xiangyang Wu, Haohao Li, Yongjia Duan, Fei Wang, Cheng Peng, Zhonghua Liu, Jie Wang, Xiaochen Huang, Lin Wang, Hua Yang, Li Wang, Wei Sha, Xia Cai, Liang-Dong Lyu, Haipeng Liu, Feng Liu, Baoxue Ge, Ruijuan Zheng   +22 more
doaj   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Chemotherapy of Pulmonary Tuberculosis [PDF]

BMJ, 1959
openaire   +4 more sources

As‐Needed Versus Regular Medication Use in the Treatment of Allergic Rhinitis in the Pollen Season: A MASK‐air Study

Allergy, EarlyView.
Using MASK‐air app data from 1042 users across 2690 weeks, this study compared the impact of regular versus as‐needed allergic rhinitis medication on symptom control and treatment satisfaction. Mixed‐effects linear regression models and sensitivity analyses revealed no significant differences between the two approaches, with results for oral ...
Bernardo Sousa‐Pinto, Rafael José Vieira, Antonio Bognanni, Ludger Klimek, Ana Margarida Pereira, Rita Amaral, Anna Bedbrook, Patrizia Bonadonna, Luisa Brussino, Mark S. Dykewicz, Mattia Giovannini, Bilun Gemicioglu, Juan Carlos Ivancevich, Violeta Kvedariene, Manuel Marques‐Cruz, Matteo Martini, André Moreira, Marek Niedoszytko, Michal Ordak, Nikolaos G. Papadopoulos, Oliver Pfaar, Nhân Pham‐Thi, Orathai Jirapongsananuruk, Frederico S. Regateiro, Sanna K. Toppila‐Salmi, Joaquin Sastre, Luís Taborda‐Barata, Ilgım Vardaloğlu Koyuncu, Arunas Valiulis, Maria Teresa Ventura, Kangsadarn Tanjararak, Yi‐Kui Xiang, Mohamed H. Shamji, Maria José Torres, Holger J. Schünemann, Danilo di Bona, João A. Fonseca, Torsten Zuberbier, Jean Bousquet   +38 more
wiley   +1 more source