Results 131 to 140 of about 917,791 (305)

REST IN PULMONARY TUBERCULOSIS. [PDF]

JAMA: The Journal of the American Medical Association, 1906
I wish to make a plea addressed to the general practitioner for the routine employment of rest in the open air in all active or partially arrested cases of tuberculosis. In the vast majority of cases the general practitioner is the man who is called on to diagnose and to treat these patients, and as he has been lectured, criticized and cajoled into ...
openaire   +2 more sources

Transforming Musculoskeletal Disorder Management With Multimodal AI Platform for Early Diagnosis, Self‐Screening, and Personalized Care

Med Research, EarlyView.
We developed a multimodal large language model‐enabled framework for the early detection, self‐screening, and personalized management of major musculoskeletal disorders, including osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP).
Pengyuan Xu, Guang Yang, Ge Zhang, Yafang Zhao, Pu Wan, Guiyun Zhou, Mengjie Jiang, Yixin Zhang, Zhaoyang Wang, Yichen Dai, Xiqing Zhao, Ziliang Fu, Ziyu Zheng, Ziyun Xu, Ruisi Dong, Xiaojie Xia, Duo Zhang, Yisheng He, Michael Moran, Qiguang Wang, Tim Woodfield, Khoon Lim, Tiantian Kong, Junnan Tang, Kang Tian, Kai Zhou, Hao Chi, Pengpeng Zhang, Jianhua Yang, Mingliang Zhang, Moyan Li, Yuan Cheng, Xiaolin Cui   +32 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: a case study of a Chinese Tuberculosis hospital

Global Health Research and Policy
Healthcare-associated infections (HAIs) represent a major global health burden, which necessitate effective frameworks to identify potential risk factors and estimate the corresponding direct economic disease burden.
Nili Ren, Xinliang Liu, Yi Luo, Guofei Li, Ying Huang, Desheng Ji, Cheng Peng, Jing Sun, Hao Li   +8 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? [PDF]

, 2005
Tuberculosis vaccine candidates are entering clinical studies in areas where BCG fails. This is a high-risk strategy. We suggest that geographical variation in the efficacy of BCG is related to the presence in developing countries of a cross-reactive ...
Rook, GAW, Dheda, K, Zumla, A
core  

Investigating Tuberculosis Dynamics Under Various Control Strategies: A Comprehensive Analysis Using Real Statistical Data

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In the present investigation, a mathematical model with vaccination, treatment, and environmental impact under real data is presented. Initially, we present the model without any interventions, followed by an examination of its equilibrium points.
Bashir Al‐Hdaibat, Mahmoud H. DarAssi, Irfan Ahmad, Muhammad Altaf Khan, Reem Algethamie   +4 more
wiley   +1 more source

Factors influencing sex differences in numbers of tuberculosis suspects at diagnostic centres in Pakistan.

, 2012
SETTING: DOTS-reporting tuberculosis (TB) diagnostic centres across Pakistan. OBJECTIVES: To quantitatively investigate the influence of diagnostic centre characteristics on the number of female and male TB suspects registered at diagnostic centres ...
Godfrey-Faussett, P., Godfrey-Faussett, P, Sismanidis, C, Khan, M. S., Khan, MS, Sismanidis, C.   +5 more
core   +1 more source