Results 41 to 50 of about 149,015 (244)

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

Advanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong, Wenyan Hao, Lingqi Xu, Yingyi Yang, Zhenzhen Dong, Peng Pan, Zhenjiang Bai, Jie Huang, Kaidi Yang, Zhu Jin, Rui Kang, Qiang Shan, Jiang huai Wang, Zijian Zhou, Daolin Tang, Jian Wang, Huiting Zhou   +16 more
wiley   +1 more source

Current landscape of exosomes in tuberculosis development, diagnosis, and treatment applications

Frontiers in Immunology
Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (MTB), remains one of the most prevalent and deadly infectious diseases worldwide. Currently, there are complex interactions between host cells and pathogens in TB. The onset,
Xuezhi Sun, Wei Li, Li Zhao, Ke Fan, Fenfen Qin, Liwen Shi, Feng Gao, Chunlan Zheng   +7 more
doaj   +1 more source

A Nano‐Electro‐Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition

Advanced Science, EarlyView.
The nano‐electro‐platform achieves non‐destructive evolutionary screening and electro‐remodeling of tumor cells to generate extracellular vesicles with enhanced tumor‐targeting and therapeutic functions. These extracellular vesicles demonstrate remarkable efficacy in activating both macrophages and T cells, thereby orchestrating a potent immune ...
Feng Liu, Hong Sun, Bing Liu, Jing Zhang, Chengbao Wu, Shi Yan, Chengzheng Tai, Yihang Tong, Rongtai Su, Xiaowei Xiang, Han Wu, Fuqi Yao, Kuan Yang, Dedong Yin, Yuqiong Wang, Ao Xiao, Long Cheng, Xi Chen, Nan Wu, Zaizai Dong, Lingqian Chang   +20 more
wiley   +1 more source

Optimized anti-tuberculosis duration for drug-susceptible pulmonary tuberculosis-diabetes mellitus comorbidities: study protocol for a multicenter randomized controlled trial

BMC Pulmonary Medicine
Background The coexistence of tuberculosis (TB) and type 2 diabetes mellitus (DM) presents unique challenges in treatment optimization and management, given the mutual exacerbation of disease processes.
Peize Zhang, Huaifang Shi, Yongping Xie, Jiemei Liang, Qiumeng Hu, Liang Fu, Yuxiang Wang, Jie Tan, Senlin Zhan, Hongjuan Qin, Guanghui Xu, Guofang Deng   +11 more
doaj   +1 more source

Paradoxical development of pleural-based masses in patients with pleural tuberculosis during treatment: a clinical observational study in China

BMC Pulmonary Medicine, 2022
Background To explored the clinical, pathological, and bacteriological characteristics of pleural-based masses occurred during anti-tuberculosis (TB) treatment in patients with pleural TB.
Zhengwei Dong, Wei Zhang, Wenwen Sun, Shaojun Zhang, Chenlu Yang, Chunyan Wu, Lin Fan   +6 more
doaj   +1 more source

Risk Factors and Predictive Models for Sarcopenia in Older Adults

AGING MEDICINE, EarlyView.
Independent risk factors for sarcopenia identified by Lasso regression and logistic regression in the study were BMI, prealbumin, albumin/globulin ratio (A/G ratio), serum creatinine, and phosphorus. These factors were used to construct a nomogram model and a decision tree model. Both models showed effectiveness in predicting sarcopenia in older adults,
Shiyuan Zhang, Xue Yang, Nina An, Meng Lv, Lanyu Yang, Rui Liu, Song Hu, Weiguo Chen, Wenjing Feng, Yongjun Mao   +9 more
wiley   +1 more source

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Diagnostic yield of Xpert MTB/RIF on contrast-enhanced ultrasound-guided pleural biopsy specimens for pleural tuberculosis

International Journal of Infectious Diseases, 2021
Background: A 3-year prospective study was conducted to evaluate the efficacy of Xpert MTB/RIF (Xpert) in the diagnosis of pleural tuberculosis (pTB) on contrast -enhanced ultrasound (CEUS)-guided pleural biopsy specimens. Method: Patients suspected with
Wenwen Sun, Yiming Zhou, Wenting Li, Yin Wang, Kunlong Xiong, Zhemin Zhang, Lin Fan   +6 more
doaj  

Using simultaneous amplification and testing method for evaluating the treatment outcome of pulmonary tuberculosis

BMC Infectious Diseases, 2018
Background To evaluate the utility of Simultaneous Amplification and Testing (SAT-TB) Method for monitoring anti-TB treatment response. Methods Serial morning sputum specimens were obtained from 377 active pulmonary tuberculosis (PTB) cases at baseline ...
Liping Yan, Heping Xiao, Qing Zhang
doaj   +1 more source

Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, Accepted Article.
Systemic vasculitis describes a collection of rare diseases each caused by inflammation of blood vessel walls that can cause severe systemic complications [[3, 4]](#ref‐0003). The pattern of vascular inflammation and resultant damage is frequently variable and may be mimicked, or directly triggered, by infection or malignancy.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source