Results 41 to 50 of about 307,106 (305)

Pulmonary tuberculosis and some underlying conditions in Golestan Province of Iran, during 2001-2005 [PDF]

, 2009
Context: Pulmonary tuberculosis has been a major health problem in Golestan province of Iran. Aims: This descriptive cross-sectional study was performed to evaluate the frequency of coexisting medical conditions and their effects on some epidemiologic ...
Dashti, M., Golsha, R., Najafi, L., Rezaei, S.R., Roshandel, G., Shafiee, A.   +5 more
core  

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Pneumocystis jirovecii pneumonia in a patient with Mycobacterium intracellulare pulmonary disease: a case report

BMC Infectious Diseases
This report details the case of a 77-year-old female with Mycobacterium intracellulare pulmonary disease and history of bladder tumor surgery. The patient initially presented to our hospital with a one-day history of fever. After receiving antibiotic and
Xiaoni Zhou, Xinhua Xiao, Yuying Wu, Jun Wang, Zhiyun Pan, Han Wang, Xiaohui Luo, Zhi Yao   +7 more
doaj   +1 more source

Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial

Emerging Microbes and Infections, 2023
In preclinical studies, a new antituberculosis drug regimen markedly reduced the time required to achieve relapse-free cure. This study aimed to preliminarily evaluate the efficacy and safety of this four-month regimen, consisting of clofazimine ...
Xubin Zheng, Xuwei Gui, Lan Yao, Jun Ma, Yifan He, Hai Lou, Jin Gu, Ruoyan Ying, Liping Chen, Qin Sun, Yidian Liu, Chih-Ming Ho, Bai-Yu Lee, Daniel L. Clemens, Marcus A. Horwitz, Xianting Ding, Xiaohui Hao, Hua Yang, Wei Sha   +18 more
doaj   +1 more source

Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study [PDF]

, 2011
Background Approximately 5-10% of persons infected with M. tuberculosis develop tuberculosis, but the factors associated with disease progression are incompletely understood.
Noffisat O Oki, Alison A Motsinger-Reif, Paulo RZ Antas, Shawn Levy, Steven M Holland, Timothy R Sterling   +5 more
core   +1 more source

The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis [PDF]

, 2003
Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the
Bongard, E, Gillespie, SH, Gosling, RD, Kanduma, EG, Morris, RW, Nyindo, M, Sam, NE, Uiso, LO   +7 more
core   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine

Nature Communications
Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis (M. tuberculosis), but the underlying mechanism remains unknown.
Cheng Peng, Yuanna Cheng, Mingtong Ma, Qiu Chen, Yongjia Duan, Shanshan Liu, Hongyu Cheng, Hua Yang, Jingping Huang, Wenyi Bu, Chenyue Shi, Xiangyang Wu, Jianxia Chen, Ruijuan Zheng, Zhonghua Liu, Zhe Ji, Jie Wang, Xiaochen Huang, Peng Wang, Wei Sha, Baoxue Ge, Lin Wang   +21 more
doaj   +1 more source

Optimizing pathological diagnosis of tuberculosis: qPCR outperforms acid-fast staining in formalin-fixed paraffin-embedded tissues and enables resistance profiling

Frontiers in Medicine
Background and ObjectiveAccurate detection of Mycobacterium tuberculosis (MTB) in formalin-fixed paraffin-embedded (FFPE) tissues remains a significant challenge in routine pathological practice.
Yan Hu, Peng Liu, Minhui Mei, Chao Quan, Qiliang Liu   +4 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source