Results 171 to 180 of about 44,285 (264)

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Concomitant Multidrug-resistant Pulmonary Tuberculosis and Susceptible Tuberculous Meningitis

Emerging Infectious Diseases, 2014
Christine Bernard, Florence Brossier, Mathilde Fréchet-Jachym, Philippe C. Morand, Sophie Coignard, Elisabeth Aslangul, Alexandra Aubry, Vincent Jarlier, Wladimir Sougakoff, Nicolas Veziris   +9 more
doaj   +1 more source

Fluoroquinolones as the linchpin of tuberculosis therapy: contrasting efficacy and resistance profiles in <i>Mycobacterium tuberculosis</i> versus <i>Mycobacterium abscessus</i>. [PDF]

Front Cell Infect Microbiol
Kuzioła M, Korycka-Machała M, Zygała-Pytlos D, Dziadek B, Kawka M, Pawełczyk J, Odolczyk N, Zielenkiewicz P, Słomka M, Dziadek J.   +9 more
europepmc   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, Volume 600, Issue 15, Page 2129-2142, August 2026.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Simultaneous molecular detection of <i>Mycobacterium tuberculosis</i> and multidrug resistance using CRISPR-AaCas12b-based nucleic acid assay. [PDF]

Front Cell Infect Microbiol
Hu Y, Zhao D, Diao Y, Bai C, Zhou K, Huang F, Li R, Hao X, Liu H, Liu J, Zhou L.   +10 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1673-1685, August 2026.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments. [PDF]

APMIS
Garcia LS, Roque-Borda CA, Pavan FR, Chorilli M.   +3 more
europepmc   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1702-1710, August 2026.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Molecular Techniques for MTBC and NTM Differentiation: Diagnostic Accuracy of STANDARD™ M10 MTB/NTM and Potential Applications. [PDF]

Diagnostics (Basel)
Genco M, Alizzi S, Valesella P, Camaggi A, Iannaccone M, Allizond V, Banche G, Bondi A, Caroppo MS, Rinaldo RF, Solidoro P, Corcione S, Calcagno A, Rossati A, Costa C, Curtoni A.   +15 more
europepmc   +1 more source