Results 191 to 200 of about 44,285 (264)

Peritoneal Tuberculosis Presenting as Massive Ascites in Pregnancy: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Abdominal tuberculosis, especially peritoneal tuberculosis, is uncommon in pregnancy. The diagnosis during pregnancy is a challenge due to many signs and symptoms being nonspecific and mimicking the symptoms of pregnancy. The presence of ascites, with anorexia and weight loss in pregnancy from endemic regions, should be addressed with ...
S. Gyamtsho, S. Dechen, S. Choden
wiley   +1 more source

Structure‐Guided Engineering of a Ser192Ala Variant Enhances Bidirectional Catalysis in Amycolatopsis sulphurea L‐Alanine Dehydrogenase

open access: yesChemCatChem, Volume 18, Issue 15, 14 August 2026.
A rationally engineered Ser192Ala variant of Amycolatopsis sulphurea L‐alanine dehydrogenase (L‐AlaDH) exhibits ∼2‐fold higher catalytic efficiency in both reductive amination and oxidative deamination. Experimental characterization confirms maintained stability under tested conditions, highlighting its potential as an improved biocatalyst for ...
Tuba Okur Aksu   +3 more
wiley   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li   +6 more
wiley   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong   +3 more
wiley   +1 more source

Protein Extraction From Mycobacterium spp. for Identification by MALDI‐TOF Mass Spectrometry

open access: yesCurrent Protocols, Volume 6, Issue 8, August 2026.
Abstract The identification of mycobacteria remains challenging due to the high species diversity within the genus and the lack of a molecular method able to identify them in a single assay. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) has been used as a rapid and promising alternative for bacterial ...
Lucas Evangelista Marques   +5 more
wiley   +1 more source

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