Results 51 to 60 of about 47,249 (313)

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]

, 2010
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Smith, H.E., Butler, R.E., Thole, J.E.R., Harders-Westerveen, S.F., Kierzek, A., Neyrolles, O., Estorninho, M., Stewart, G.R.   +7 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Identification and characterisation of endogenous inducible promoters in Mycobacterium tuberculosis [PDF]

, 2010
PhDMycobacterium tuberculosis is one of the world’s most devastating pathogens. Despite completion of the genome sequence in 1998, research progress has been hampered by a lack of genetic tools and the difficulty of working with the organism. Existing
Schuessler, Dorothée Laura
core  

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Kishore, U, Leiva, S, Robertson, BD, Rosenkrands, I, Nagy, J, Tsolaki, AG   +5 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection [PDF]

, 2015
Ethiopia, a high tuberculosis (TB) burden country, reports one of the highest incidence rates of extra-pulmonary TB dominated by cervical lymphadenitis (TBLN).
Wondale Mekonnen, Rea Tschopp, Gordon, Stephen V, Firdessa, Rebuma, Kiros, T, Yamuah, Lawrence, Gagneux, Sebastien, Habtamu, M, Hussein, J, Hewinson, G, Araya Mengistu, Aseffa, Abraham, Hailu, Elena, Elena Hailu, Gadisa, Endalamaw, Robertson, BD, Zinsstag, J, Hussein, Jemal, Brian D Robertson, Esther Schelling, Berg, Stefan, Tschopp, R, Aseffa, A, Rebuma Firdessa, Glyn Hewinson, Kiros, Teklu, Berg, S, Stefan Berg, Robertson, Brian D., Shiferaw Bekele, Mengistu, A, Meseret Habtamu, Gordon, SV, Abraham Aseffa, Lawrence Yamuah, Yohannes Derese, Firdessa, R, Erenso, G, Stephen V Gordon, Gadisa, E, Yamuah, L, Gumi, Balako, Habtamu, Meseret, Gumi, B, Robertson, Brian D, Balako Gumi, Derese, Y, Bekele, S, Gobena Ameni, Mekonnen, W, Mengistu, Araya, Hailu, E, Tschopp, Rea, Girume Erenso, Erenso, Girume, Hewinson, Glyn, Endalamaw Gadisa, Gagneux, S, Derese, Yohannes, Mekonnen, Wondale, Bekele, Shiferaw, Sebastien Gagneux, Ameni, G, Zinsstag, Jakob, Schelling, E, Ameni, Gobena, Schelling, Esther, Gordon, Stephen V., Jemal Hussein, Jakob Zinsstag, Teklu Kiros   +70 more
core   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Limited Capability for Testing Mycobacterium tuberculosis for Susceptibility to New Drugs

Emerging Infectious Diseases, 2021
We surveyed availability of phenotypic drug susceptibility testing for drug-resistant Mycobacterium tuberculosis in Europe. Of 27 laboratories, 17 tested for linezolid, 11 for clofazimine, 9 for bedaquiline, and 6 for delamanid during 2019.
Hamzah Z. Farooq, Daniela M. Cirillo, Doris Hillemann, David Wyllie, Marieke J. van der Werf, Csaba Ködmön, Vlad Nikolayevskyy   +6 more
doaj   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source