Results 51 to 60 of about 49,519 (255)

Interferon-gamma and skin test responses of schoolchildren in southeast England to purified protein derivatives from Mycobacterium tuberculosis and other species of mycobacteria.

, 2003
The immune responses of schoolchildren in southeast England to Mycobacterium tuberculosis and other species of mycobacteria were studied prior to vaccination with bacille Calmette-Guérin (BCG).
Branson, K, King, E, Dockrell, HM, Black, GF, Weir, RE, Bliss, L, Fine, PEM, Nazareth, B, Stanley, C, Floyd, S   +9 more
core   +1 more source

Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates [PDF]

, 2005
Objectives: Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and ...
Basu, Shreya, O'Sullivan, D M, McHugh, TD, O'Sullivan, Denise M, Gillespie, S H, Dickens, A L, McHugh, T D, O'Sullivan, DM, Basu, S, Gillespie, Stephen H, Gillespie, SH, Dickens, AL, Dickens, Anne L, McHugh, Timothy D   +13 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Limited Capability for Testing Mycobacterium tuberculosis for Susceptibility to New Drugs

Emerging Infectious Diseases, 2021
We surveyed availability of phenotypic drug susceptibility testing for drug-resistant Mycobacterium tuberculosis in Europe. Of 27 laboratories, 17 tested for linezolid, 11 for clofazimine, 9 for bedaquiline, and 6 for delamanid during 2019.
Hamzah Z. Farooq, Daniela M. Cirillo, Doris Hillemann, David Wyllie, Marieke J. van der Werf, Csaba Ködmön, Vlad Nikolayevskyy   +6 more
doaj   +1 more source

Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection [PDF]

, 2015
Ethiopia, a high tuberculosis (TB) burden country, reports one of the highest incidence rates of extra-pulmonary TB dominated by cervical lymphadenitis (TBLN).
Wondale Mekonnen, Rea Tschopp, Gordon, Stephen V, Firdessa, Rebuma, Kiros, T, Yamuah, Lawrence, Gagneux, Sebastien, Habtamu, M, Hussein, J, Hewinson, G, Araya Mengistu, Aseffa, Abraham, Hailu, Elena, Elena Hailu, Gadisa, Endalamaw, Robertson, BD, Zinsstag, J, Hussein, Jemal, Brian D Robertson, Esther Schelling, Berg, Stefan, Tschopp, R, Aseffa, A, Rebuma Firdessa, Glyn Hewinson, Kiros, Teklu, Berg, S, Stefan Berg, Robertson, Brian D., Shiferaw Bekele, Mengistu, A, Meseret Habtamu, Gordon, SV, Abraham Aseffa, Lawrence Yamuah, Yohannes Derese, Firdessa, R, Erenso, G, Stephen V Gordon, Gadisa, E, Yamuah, L, Gumi, Balako, Habtamu, Meseret, Gumi, B, Robertson, Brian D, Balako Gumi, Derese, Y, Bekele, S, Gobena Ameni, Mekonnen, W, Mengistu, Araya, Hailu, E, Tschopp, Rea, Girume Erenso, Erenso, Girume, Hewinson, Glyn, Endalamaw Gadisa, Gagneux, S, Derese, Yohannes, Mekonnen, Wondale, Bekele, Shiferaw, Sebastien Gagneux, Ameni, G, Zinsstag, Jakob, Schelling, E, Ameni, Gobena, Schelling, Esther, Gordon, Stephen V., Jemal Hussein, Jakob Zinsstag, Teklu Kiros   +70 more
core   +2 more sources

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
Porcelli, SA, Wang, Yanhua, Steven A. Porcelli, William R Jacobs, Flynn, Joanne L, Chen, Y, John Chan, Kozakiewicz, Lee, Qinglin Ou, Lee Kozakiewicz, Chan, John, Xu, J, Ou, Qinglin, Yong Chen (109188), John Chan (47914), Jacobs, WR, Flynn, JL, Ou, Q, Jacobs, William R, William R. Jacobs, Dunussi-Joannopoulos, K, Dunussi-Joannopoulos, Kyri, Steven A. Porcelli (47915), Chen, Yong, Joanne L Flynn, Xu, Jiayong, Kozakiewicz, L, Jiayong Xu (432778), Wang, Y, Joanne L. Flynn (5655565), William R. Jacobs Jr (199645), Chan, J, Lee Kozakiewicz (432777), Qinglin Ou (432779), Joanne L. Flynn, Yanhua Wang, Porcelli, Steven A, Yanhua Wang (127897), Jiayong Xu, Steven A Porcelli, Yong Chen, Kyri Dunussi-Joannopoulos, Kyri Dunussi-Joannopoulos (344714)   +42 more
core   +2 more sources

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source

Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB [PDF]

, 2012
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB ...
Fernández, Raquel, Nicholas J Loman, Besra, Gurdyal S., Ballell, L, Raquel Fernández, Pallen, Mark J., Abrahams, Katherine A, Loman, Nicholas J., Abrahams, Katherine A., Spivey, VL, Constantinidou Chrystala, Mark J Pallen, Remuiñán, Modesto J, Cox, Jonathan A G, Abrahams Katherine A., Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Cox Jonathan A. G., Loman, NJ, Besra, GS, Constantinidou, Chrystala, Alemparte Carlos, Pallen, Mark J, Besra, Gurdyal S; id_orcid, Abrahams, KA, Remuiñán, Modesto J., Besra Gurdyal S., Remuiñán Modesto J., Vickey L Spivey, Chrystala Constantinidou, Pallen, MJ, Barros, D, Loman Nicholas J., Ballell, Lluis, Fernández, R, Alemparte, Carlos, Cox, Jonathan A. G., Cox, JA, Modesto J Remuiñán, Barros David, Jonathan A G Cox, Gurdyal S Besra, Fernández Raquel, Spivey, Vickey L., David Barros, Constantinidou, C, Ballell Lluis, Spivey Vickey L., Barros, David, Spivey, Vickey L, Pallen Mark J., Remuiñán, MJ, Alemparte, C, Katherine A Abrahams   +54 more
core   +2 more sources

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source