Results 61 to 70 of about 47,249 (313)

Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB [PDF]

, 2012
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB ...
Fernández, Raquel, Nicholas J Loman, Besra, Gurdyal S., Ballell, L, Raquel Fernández, Pallen, Mark J., Abrahams, Katherine A, Loman, Nicholas J., Abrahams, Katherine A., Spivey, VL, Constantinidou Chrystala, Mark J Pallen, Remuiñán, Modesto J, Cox, Jonathan A G, Abrahams Katherine A., Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Cox Jonathan A. G., Loman, NJ, Besra, GS, Constantinidou, Chrystala, Alemparte Carlos, Pallen, Mark J, Besra, Gurdyal S; id_orcid, Abrahams, KA, Remuiñán, Modesto J., Besra Gurdyal S., Remuiñán Modesto J., Vickey L Spivey, Chrystala Constantinidou, Pallen, MJ, Barros, D, Loman Nicholas J., Ballell, Lluis, Fernández, R, Alemparte, Carlos, Cox, Jonathan A. G., Cox, JA, Modesto J Remuiñán, Barros David, Jonathan A G Cox, Gurdyal S Besra, Fernández Raquel, Spivey, Vickey L., David Barros, Constantinidou, C, Ballell Lluis, Spivey Vickey L., Barros, David, Spivey, Vickey L, Pallen Mark J., Remuiñán, MJ, Alemparte, C, Katherine A Abrahams   +54 more
core   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
Porcelli, SA, Wang, Yanhua, Steven A. Porcelli, William R Jacobs, Flynn, Joanne L, Chen, Y, John Chan, Kozakiewicz, Lee, Qinglin Ou, Lee Kozakiewicz, Chan, John, Xu, J, Ou, Qinglin, Yong Chen (109188), John Chan (47914), Jacobs, WR, Flynn, JL, Ou, Q, Jacobs, William R, William R. Jacobs, Dunussi-Joannopoulos, K, Dunussi-Joannopoulos, Kyri, Steven A. Porcelli (47915), Chen, Yong, Joanne L Flynn, Xu, Jiayong, Kozakiewicz, L, Jiayong Xu (432778), Wang, Y, Joanne L. Flynn (5655565), William R. Jacobs Jr (199645), Chan, J, Lee Kozakiewicz (432777), Qinglin Ou (432779), Joanne L. Flynn, Yanhua Wang, Porcelli, Steven A, Yanhua Wang (127897), Jiayong Xu, Steven A Porcelli, Yong Chen, Kyri Dunussi-Joannopoulos, Kyri Dunussi-Joannopoulos (344714)   +42 more
core   +1 more source

Pseudoepidemic of mycobacteria other tuberculosis(MOTT) due to contaminated bronchoscope. [PDF]

Tuberculosis and Respiratory Diseases, 1970
Background: The development of the flexible fiberoptic broncoscope by Ikeda was an important technologic advance in the diagnosis and management of patients with pulmonary disease. But, cross contamination related to fiberoptic bronchoscope was reported in cases involving tubercle bacilli, MOTT and other agents.
Seung Min Kwak, Se Kyu Kim, Joong Hyun Jang, Hong Lyeol Lee, Yi Hyung Lee, Sung Kyu Kim, Won Young Lee, Yoon Sup Jeong   +7 more
openaire   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Isolamento e identificação de micobactérias não-tuberculosas em laboratório e hospital de referência do Estado de Santa Catarina [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaIntrodução: O gênero Mycobacterium compreende mais de 150 espécies, incluindo patogênicas, oportunistas e não patogênicas ...
Wildner, Letícia Muraro
core  

Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin [PDF]

, 2008
OBJECTIVES: To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis.
Butcher, P. D., Hinds, J., O'Sullivan, DM, Butcher, PD, Gillespie, Stephen Henry, Hinds, J, McHugh, TD, Gillespie, SH, O'Sullivan, D. M., McHugh, T. D.   +9 more
core   +1 more source

Metabolic activity of mature biofilms of Mycobacterium tuberculosis and other non-tuberculous mycobacteria [PDF]

Scientific Reports, 2017
AbstractMycobacteria are classified into two groups, fast- and slow-growing. Often, fast-growing mycobacteria are assumed to have a higher metabolic activity than their slower counterparts, but in mature biofilms this assumption might not be correct.
Solokhina A, Brückner D, Bonkat G, Braissant O   +3 more
openaire   +4 more sources

Tuberculosis in Kindergarten and Primary School, Italy, 2008–2009

Emerging Infectious Diseases, 2011
An outbreak of tuberculosis (TB) in Italy involved 19 schoolchildren with active TB and 43 with latent infection. The source of the outbreak was a school assistant born in Italy who had a family history of TB.
Antonietta Filia, Giuseppe Ciarrocchi, Rossana Belfiglio, Monaldo Caferri, Antonino Bella, Claudio Piersimoni, Daniela Cirillo, Gualtiero Grilli, Cristina Mancini, Donato Greco   +9 more
doaj   +1 more source