Results 71 to 80 of about 47,249 (313)

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains [PDF]

, 2014
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance.
Glynn, Judith R., Clark, T.G., Perdigão, João, Judith R. Glynn, McNerney, R., McNerney, Ruth, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Guerra-Assunção, J.A., Coll, Francesc, Viveiros, Miguel, Isabel Portugal, Clark, Taane G., Perdigão, J., Pain, A., Pain, Arnab, Glynn, J.R., Jose ́ Afonso Guerra-assunção, Portugal, I., Ruth Mcnerney, Miguel Viveiros, Francesc Coll, Portugal, Isabel, Martin, Nigel, Arnab Pain, Nigel Martin, Taane G. Clark, Coll, F., Clark, Taane G   +29 more
core   +1 more source

Incidence of Pulmonary Disease Caused by Mycobacteria other than Tuberculosis in British Columbia [PDF]

Canadian Respiratory Journal, 2002
CONTEXT: The incidence of pulmonary disease due to mycobacteria other than tuberculosis (TB) in Canada has not been documented.OBJECTIVE: To determine the incidence of pulmonary disease due to mycobacteria in the nonimmunocompromised population of British Columbia.DESIGN: A retrospective cohort study of 110 cases of mycobacteria infection other than TB
R Kevin Elwood, Anabelle M Opazo Saez, Vittorio Lentini, Ramak Shadmani   +3 more
openaire   +3 more sources

Mycobacterium tuberculosis Genotype and Case Notification Rates, Rural Vietnam, 2003–2006

Emerging Infectious Diseases, 2009
Tuberculosis case notification rates (CNRs) for young adults in Vietnam are increasing. To determine whether this finding could reflect emergence of Mycobacterium tuberculosis Beijing genotype, we studied all new sputum smear–positive pulmonary ...
Tran N. Buu, Mai N.T. Huyen, Nguyen N.T. Lan, Hoang T. Quy, Nguyen V. Hen, Matteo Zignol, Martien W. Borgdorff, Dick van Soolingen, Frank G.J. Cobelens   +8 more
doaj   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Cigarette smoke and human pulmonary immune responses to mycobacteria [PDF]

, 2011
Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells ...
Van Zyl-Smit, Richard Nellis
core  

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. [PDF]

, 2009
BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M.
Hussain Rabia, Cliff, Jacqueline M., Hasan, Z, Jamil, Bushra, Bushra Jamil, Hussain, Rabia, Cliff, Jacqueline M, Ashraf Mussarat, Hazel M Dockrell, Hasan Zahra, Jamil, B, Mussarat Ashraf, Jacqueline M Cliff, Ashraf, Mussarat, Cliff Jacqueline M., Cliff, JM, Irfan, Muhammad, Irfan Muhammad, Ashraf, M, Hussain, R, Muhammad Irfan, Hasan, Zahra, Dockrell Hazel M., Dockrell, HM, Irfan, M, Jamil Bushra, Dockrell, Hazel M, Rabia Hussain, Zahra Hasan   +28 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Mycobacteria Other than Tuberculosis Producing Disease in a Tertiary Referral Hospital

Annals of Saudi Medicine, 1993
Over the period of 1987 to 1989, three hundred and two isolates of ten species of mycobacteria other than tuberculosis (MOTT) produced disease in 282 patients. M. avium intracellulare was the most common (53% patients), followed by M. gordonae and M. fortuitum-chelonae (20%).
M E, Ellis, S M, Qadri
openaire   +2 more sources

Latent Tuberculosis Screening Using Electronic Health Record Data

Emerging Infectious Diseases, 2020
Screening for latent tuberculosis infection is recommended for foreign-born persons in the United States. We used proxy data from electronic health records to determine that 17.5% of foreign-born outpatients attending the UC San Diego Health clinic (San ...
Jeffrey D. Jenks, Richard S. Garfein, Wenhong Zhu, Michael Hogarth   +3 more
doaj   +1 more source