Results 111 to 120 of about 436,730 (400)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]
, 2011 There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana +7 more
core +2 more sources
An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance
International Journal of Molecular Sciences, 2017 Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular functions throughout all phases of the cell cycle. Altered tubulin isotype composition of microtubules is emerging as a feature of aggressive and treatment ...
Amelia L. Parker +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Neuron Growth Output-Feedback Control by PDE Backstepping [PDF]
arXiv, 2022 Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the extracellular matrix, the network of extracellular macromolecules, and minerals that control the tubulin protein ...
arxiv
Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.
Journal of Medicinal Chemistry, 2016 The unique characteristics of the tumor vasculature offer the possibility to selectively target tumor growth and vascularization using tubulin-destabilizing agents.
M. Pérez-Pérez +5 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
TUBB4B is essential for the expansion of differentiating spermatogonia
Scientific ReportsMicrotubules, polymers of αβ-tubulin heterodimers, are essential for various cellular processes. The incorporation of different tubulin isotypes, each encoded by distinct genes, is proposed to contribute to the functional diversity observed in ...
Urikhan Sanzhaeva +3 more
doaj +1 more source
The Journal of Cell Biology, 2002 ![Graphic][1] Conoids consist of tubulin in an unconventional arrangement.The pathogens that cause malaria, cryptosporidiosis, and toxoplasmosis share a baffling common feature: a cone-shaped apical structure called the conoid.
openaire +2 more sources
A Unifying Hypothesis for the Conformational Change of Tubulin [PDF]
arXiv, 2001 Microtubule dynamic instability arises from the hydrolysis of GTP bound to the beta-monomer of the tubulin dimer. The conformational change induced by hydrolysis is unknown, but microtubules disassemble into protofilaments of GDP-bound tubulin that curve away from the microtubule axis.
arxiv