Results 111 to 120 of about 292,166 (345)
Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth
Advanced Functional Materials, EarlyView.Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung +8 more
wiley +1 more source
The tubulin code: Molecular components, readout mechanisms, and functions
Journal of Cell Biology, 2014 Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the properties and architecture of microtubules are highly conserved in ...
C. Janke
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source
Phytopathology, 2016 Tubulins are the proposed target of clinically relevant anticancer drugs, anthelmintic, and fungicide. β2-tubulin of the plant pathogen Fusarium graminearum was considered as the target of benzimidazole compounds by homology modeling in our previous work.
Yujun Zhou +4 more
semanticscholar +1 more source
Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa +5 more
wiley +1 more source
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly
Scientific Reports, 2015 Cilia play important roles in sensing extracellular signals and directing fluid flow. Ciliary dysfunction is associated with a variety of diseases known as ciliopathies.
J. Ran +4 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin +19 more
wiley +1 more source
Simultaneous localization of myosin and tubulin in human tissue culture cells by double antibody staining [PDF]
, 1978 Keigi Fujiwara, TD Pollard
openalex +1 more source
The tubulin code and its role in controlling microtubule properties and functions
Nature reviews. Molecular cell biology, 2020 C. Janke, M. Magiera
semanticscholar +1 more source