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Tumor-associated macrophages: a molecular perspective
International Immunopharmacology, 2002The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors.
SICA, Antonio, Saccani A, Mantovani A.
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Targeting Tumor-Associated Macrophages in Cancer
Trends in Immunology, 2019Macrophages are phagocytes that serve as a first line of defense against pathogenic insults to tissues. These innate immune cells mount proinflammatory responses to pathogens and repair damaged tissues. However, tumor-associated macrophages (TAMs) express cytokines and chemokines that can suppress antitumor immunity and promote tumor progression ...
Paulina, Pathria +2 more
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Tumor-Associated Macrophages in Breast Cancer
Journal of Mammary Gland Biology and Neoplasia, 2002Neoplastic cells form only one part of a complex network of cell types that make up a breast tumor. The normal cell types that make up the nonneoplastic components of tumors include fibroblasts, endothelium, and inflammatory cells, such as tumor associated macrophages (TAMs).
Russell D, Leek, Adrian L, Harris
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Tumor-associated macrophages in thoracic malignancies
Lung Cancer, 2013Tumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest.
Lievense, Sanne +3 more
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Pathophysiology of Tumor‐Associated Macrophages
Advances in clinical chemistry, 2008The macrophage is an important component of the human immune defense mechanism. Cancer cells secrete a variety of chemoattractants that attract macrophages and cause them to accumulate in the tumor tissue, wherein the macrophage becomes a tumor-associated macrophage (TAM).
Ang, Yuan +2 more
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Current methods for tumor-associated macrophages investigation
Journal of Immunoassay and Immunochemistry, 2018Oncoimmunology is a rapidly growing field, focusing both on studying of the interaction of immune factors with tumor cells and also on the development of new therapies. In this regard, immunotherapy is increasingly used clinically. Although tumorigenesis is generally seen as an autonomous process involving genetically transformed cancer cells, it is ...
Alice, Grigore +2 more
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Reprogramming tumor-associated macrophages using exosomes from M1 macrophages
Biochemical and Biophysical Research CommunicationsMacrophages, abundant in tumors, are classified as M1 or M2 types with M2 dominating the tumor microenvironment. Shifting macrophages from M2 to M1 using exosomes is a promising intervention. The properties of exosomes depend on their source cells. M1-exosomes are expected to polarize macrophages towards M1 phenotype.
Mohammad Mahmoudi +5 more
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Modulating the tumor-associated macrophage landscape
Nature Immunology, 2022Boissonnas, Alexandre +1 more
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