Results 71 to 80 of about 93,268 (298)

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment

Journal of Inflammation Research, 2021
Min Luo,1 Yan Lin,1 Rong Liang,1 Yongqiang Li,1 Lianying Ge2 1Department of Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China; 2Department of Endoscopy, Guangxi Medical University Cancer Hospital ...
Luo M, Lin Y, Liang R, Li Y, Ge L
doaj  

CD103 is a hallmark of tumor-infiltrating regulatory T cells

, 2011
Regulatory T cells (Treg) mediate tolerance towards self-antigens by suppression of innate and adaptive immunity. In cancer patients, tumor-infiltrating FoxP3+ Treg suppress local anti-tumor immune responses and are often associated with poor prognosis ...
Golic, M., Ellwart, J.W., Jonathan Ellermeier, Schnurr, M., Anz, David, Endres, S., Schnurr, Max, Kunz, W.G., Michaela Golic, Ellermeier, Jonathan, Rapp, Moritz, Ellwart, Joachim W., Ellwart, Joachim W, Kunz, Wolfgang G., Koelzer, V.H., Viktor H. Koelzer, Mueller, W., Stefan Endres, David Anz, Anz, D., Kölzer, Viktor H., Koelzer, Viktor H., Carole Bourquin, Golic, Michaela, Wolfgang Mueller, Wolfgang G. Kunz, Koelzer, Viktor H; https://orcid.org/, Ellermeier, J., Joachim W. Ellwart, Moritz Rapp, Mueller, Wolfgang, Max Schnurr, Bourquin, Carole, Rapp, M., Endres, Stefan, Bourquin, C., Kunz, Wolfgang G   +36 more
core   +1 more source

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
Kumar, D, S V Hodgson, D Kumar, Beggs, A D; id_orcid, S K Ganapathi, Hodgson, SV, Hodgson, S V, Ganapathi, SK, Beggs, AD, Ganapathi, S K, A D Beggs   +10 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

npj Breast Cancer, 2022
The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system.
Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A. Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice André, Carsten Denkert, Martine Piccart, Elvire Roblin, Stefan Michiels   +22 more
doaj   +1 more source

Lesion-Specific Activation of Cloned Human Tumor-Infiltrating Lymphocytes by Autologous Tumor Cells: Induction of Proliferation and Cytokine Production

, 1993
To investigate the mechanisms by which tumor-infiltrating lymphocytes exert their antitumor effects, tumor-specific tumor-infiltrating lymphocyte clones, as well as autologous tumor cell lines from primary and secondary tumors of two patients during the ...
Burg, Günter, Becker, Jürgen C, Bröcker, Eva-Bettina, Schwinn, Andreas, Dummer, Reinhard   +4 more
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

The global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis

Frontiers in Immunology
BackgroundThe body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.ObjectiveThis study utilizes bibliometric methodologies to identify emerging ...
Beibei Wu, Beibei Wu, Beibei Wu, Ding Luo, Ding Luo, Xuejie Wang, Xuejie Wang, Chen Qiao, Chen Qiao, Rui Li, Jian Liu, Jian Liu   +11 more
doaj   +1 more source

An open source automated tumor infiltrating lymphocyte algorithm for prognosis in melanoma

Nature Communications, 2019
Histology data exists for many cancer samples and the ability to automatically image this data may provide prognostic information. Here, the authors generated an algorithm to measure tumour infiltrating lymphocytes in melanoma histology specimens and ...
Balazs Acs, Fahad Shabbir Ahmed, Swati Gupta, Pok Fai Wong, Robyn D. Gartrell, Jaya Sarin Pradhan, Emanuelle M. Rizk, Bonnie Gould Rothberg, Yvonne M. Saenger, David L. Rimm   +9 more
doaj   +1 more source