Results 101 to 110 of about 337,127 (342)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

Breast Cancer Research, 2019
The presence of tumor-infiltrating lymphocytes (TILs) is correlated with good prognosis and outcome after (immuno)therapy in triple-negative and HER2-positive breast cancer. However, the role of TILs in luminal breast cancer is less clear.
M. Sobral-Leite, Izhar Salomon, M. Opdam, D. Kruger, K. Beelen, V. van der Noort, R. V. van Vlierberghe, E. J. Blok, D. Giardiello, J. Sanders, K. K. van de Vijver, H. Horlings, P. Kuppen, S. Linn, M. Schmidt, M. Kok   +15 more
semanticscholar   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

B and T Tumor-Infiltrating Lymphocyte Subtypes According to Subsite: A Colon Cancer Immunophenotyping Map

Biomedicines
Background: Accumulating evidence regarding the association between tumor-infiltrating lymphocyte (TIL) subtypes and prognosis in colorectal cancer has emerged recently in the literature.
Giorgiana Fagarasan, Bogdan Alexandru Gheban, Vlad Fagarasan, Doinita Crisan, Teodora Telecan, Vasile Virgil Bintintan, Radu Ioan Seicean, Alexandra Caziuc, George Calin Dindelegan   +8 more
doaj   +1 more source

Tumor infiltrating lymphocytes in malignant melanoma - allies or foes?

Biomedical Papers, 2020
This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of ...
Vladimir Zidlik, Michala Bezdekova, Svetlana Brychtova   +2 more
doaj   +1 more source

Multiplex quantitative analysis of tumor-infiltrating lymphocytes and immunotherapy outcome in metastatic melanoma

Clinical Cancer Research, 2019
Purpose: Because durable response to programmed cell death 1 (PD-1) inhibition is limited to a subset of melanoma patients, new predictive biomarkers could have clinical utility.
Pok Fai Wong, Wei Wei, J. Smithy, Balasz Acs, Maria I Toki, K. Blenman, D. Zelterman, H. Kluger, D. Rimm   +8 more
semanticscholar   +1 more source

Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes

, 2019
Aim: To determine if silencing PD-1 on tumor-infiltrating lymphocytes (TILs) and its ligand-1 (PD-L1) on cancer cells will enhance the cytotoxicity of TILs.
Chen, Chen, Xu, Zhi Ping, Gu, Wenyi, Li, Jiang, Wu, Yanheng   +4 more
core   +1 more source

Tumor-infiltrating lymphocyte: features and prognosis of lymphocytes infiltration on colorectal cancer

, 2023
Tumor-infiltrating lymphocytes (TILs) are vital elements of the tumor microenvironment (TME), and the anti-tumor activity of TILs on colorectal cancer (CRC) has been a topic of concern.
Miao Qin (724772), Guangxian Xu (797319), Lina Wang (44695), Gang Chen (107840), Ye Hu (71531), Qunfeng Wang (8829419), Bei Xie (12149745), Jinxia Hou (14404635), Dan Jiang (139681), Hulai Wei (14404638), Li Wang (15202), Jing Chen (4762)   +11 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Prognostic significance of CD8 + tumor-infiltrating lymphocytes in operable breast cancer: a meta-analysis

BMC Cancer
Background As key mediators of antitumor immunity, CD8 + tumor-infiltrating lymphocytes present antigens and initiate robust immune responses against cancer cells.
Ruijie Niu, Cheng Wang, Yiqun Xie, Shuangshuang Li, Qian Zhao, Yuqing Chang, Zubing Mei   +6 more
doaj   +1 more source