Results 91 to 100 of about 337,127 (342)

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Tumor-infiltrating B lymphocytes as an efficient source of highly specific immunoglobulins recognizing tumor cells-5

, 2011
Copyright information:Taken from "Tumor-infiltrating B lymphocytes as an efficient source of highly specific immunoglobulins recognizing tumor cells"http://www.biomedcentral.com/1472-6750/7/70BMC Biotechnology 2007;7():70-70.Published online 18 Oct ...
Daniela Santapaola (59975), Fiorella Petronzelli (58573), Angela Pelliccia (58576), Rita De Santis (58578), Olga Minenkova (5454), Giorgia Monteriù (5445), Valeria D'Alessio (58575), Emiliano Pavoni (5442), Anna Maria Anastasi (58574)   +8 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility

Nature Communications
Immune checkpoint inhibition has shown success in treating metastatic cutaneous melanoma but has limited efficacy against metastatic uveal melanoma, a rare variant arising from the immune privileged eye.
Shravan Leonard-Murali, Chetana Bhaskarla, Ghanshyam S. Yadav, Sudeep K. Maurya, Chenna R. Galiveti, Joshua A. Tobin, Rachel J. Kann, Eishan Ashwat, Patrick S. Murphy, Anish B. Chakka, Vishal Soman, Paul G. Cantalupo, Xinming Zhuo, Gopi Vyas, Dara L. Kozak, Lindsey M. Kelly, Ed Smith, Uma R. Chandran, Yen-Michael S. Hsu, Udai S. Kammula   +19 more
doaj   +1 more source

Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal Cancer

Scientific Reports, 2019
Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accumulate within DNA; making them more prone to attack by tumor infiltrating lymphocytes (TIL) and macrophages.
Sumana Narayanan, T. Kawaguchi, X. Peng, Qianya Qi, Song Liu, Li Yan, K. Takabe   +6 more
semanticscholar   +1 more source

Tumor-infiltrating lymphocytes in LUAD patients with low or high risk scores.

, 2023
(A) Heatmap of differentially expressed genes between the high and low risk score groups. (B) GO enrichment analyses of differentially expressed genes between the high and low risk score groups. (C) Single-sample GSEA of tumor-infiltrating immune cells. (
Zhen Wang (72451), Sheng-Cai Zheng (1633369), Qing-Yu Chen (15309286), Xin Qiao (1625608), Ya-Lan Liu (1822909), Zhong-Yin Huang (12052223), Feng-Shuang Yi (11631277), Ming-Ming Shao (11631274), Kan Zhai (444378), Huan-Zhong Shi (169095)   +9 more
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.

PLoS ONE, 2020
BACKGROUND:Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear.
Kazushige Koike, Hironari Dehari, Kazuhiro Ogi, Shota Shimizu, Koyo Nishiyama, Tomoko Sonoda, Takanori Sasaki, Takashi Sasaya, Kei Tsuchihashi, Tadashi Hasegawa, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Akihiro Miyazaki   +12 more
doaj   +1 more source

Prognostic Impact of Tumor-Infiltrating Lymphocytes and Neutrophils on Survival of Patients with Upfront Resection of Pancreatic Cancer

Cancers, 2019
In patients with pancreatic ductal adenocarcinoma (PDAC), the tumor microenvironment consists of cellular and stromal components that influence prognosis. Hence, tumor-infiltrating lymphocytes (TILs) may predict prognosis more precisely than conventional
R. Miksch, M. Schoenberg, M. Weniger, F. Bösch, S. Ormanns, B. Mayer, J. Werner, A. Bazhin, J. D'haese   +8 more
semanticscholar   +1 more source

Multiplex Quantitative Analysis of Tumor-Infiltrating Lymphocytes, Cancer-Associated Fibroblasts, and CD200 in Pancreatic Cancer

, 2021
Pancreatic cancer is marked by a desmoplastic tumor microenvironment and low tumor immunogenicity, making it difficult for immunotherapy drugs to improve outcomes for patients. Tumor-infiltrating lymphocytes (TILs) and cancer-associated fibroblasts (CAFs)
Ioannis A. Vathiotis, Thazin Nwe Aung, Aaron M. Gruver, David L. Rimm, Jon Zugazagoitia, Saba Shafi, Tyler MacNeil, Kyla Driscoll   +7 more
core   +1 more source