Advanced Science, EarlyView.Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu +7 more
wiley +1 more source
Efficacy of treatment with tumor-infiltrating lymphocytes as adoptive cell therapy: an integrative review. [PDF]
Einstein (Sao Paulo)Silva LMSD +5 more
europepmc +1 more source
Advanced Science, EarlyView.Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang +8 more
wiley +1 more source
Characteristics of successful expansion of tumor-infiltrating lymphocytes from colorectal cancer liver metastasis. [PDF]
Sci RepBaek J +8 more
europepmc +1 more source
Advanced Science, EarlyView.To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo +3 more
wiley +1 more source
Development of a prognostic model for breast cancer patients based on intratumoral tumor-infiltrating lymphocytes using machine learning algorithms. [PDF]
Discov OncolWu X, Li C.
europepmc +1 more source
Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy
Advanced Science, EarlyView.Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang +3 more
wiley +1 more source
Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic <i>BRCA</i> variants in high-grade serous ovarian carcinoma. [PDF]
Front Med (Lausanne)Nguyen-Phan DH +9 more
europepmc +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
Advanced Science, EarlyView.This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li +8 more
wiley +1 more source