Results 311 to 320 of about 159,317 (346)

Clonal dynamics of tumor-infiltrating lymphocytes

European Journal of Immunology, 2005
The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Hiroyuki Tahara, Kazuhiko Yamamoto, Keishi Fujio, Rong Yu, Yasuto Araki   +4 more
openaire   +3 more sources

Tumor-Infiltrating Lymphocytes

Acta Cytologica, 1996
To characterize the cytologic, phenotypic and morphometric features of tumor-infiltrating lymphocytes (TILs).Morphology and cell size parameters of 50 TILs and five normal donor peripheral blood lymphocyte (PBL) specimens were compared using light microscopy, manual ocular measurements and digital image processing.Cytologically, all TILs demonstrated ...
Diane Solomon, Gary W. Oliver, John Yannelli   +2 more
openaire   +3 more sources

Reporting Tumor Infiltrating Lymphocytes

2012
The presence of many tumor infiltrating lymphocytes (TILs) in primary cutaneous melanoma is associated with a better prognosis. The degree of lymphocytic interaction with the tumor cells is graded as “brisk”, “non-brisk” or “absent” as defined below:
Kasia Szyfelbein Masterpol, Lyn M. Duncan, Andrea Primiani   +2 more
openaire   +2 more sources

Tumor-infiltrating lymphocytes and POLE mutation in endometrial carcinoma

Gynecologic Oncology, 2021
Polymerase-ε (POLE)-mutated endometrial carcinomas (ECs) have displayed an increased number of tumor-infiltrating lymphocytes (TIL) compared to POLE-wild-type ECs. However, it is unclear if TIL may aid in identifying POLE-mutated ECs when molecular data are unavailable.
Raffone A., Travaglino A., Raimondo D., Boccellino M. P., Maletta M., Borghese G., Casadio P., Insabato L., Mollo A., Zullo F., Seracchioli R.   +10 more
openaire   +5 more sources

Tumor-Infiltrating Lymphocyte Therapy and Neoantigens

The Cancer Journal, 2017
The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
openaire   +3 more sources

Clinical Significance of Tumor-Infiltrating Lymphocytes in Lung Neoplasms [PDF]

The Annals of Thoracic Surgery, 2009
Tumor-infiltrating lymphocytes (TIL) are considered important in anticancer immunosurveillance, although their role has not been clearly established yet. We examined prevalence, correlations, and prognostic significance of TIL among our patient population of resected lung neoplasms.From 1993 to 2006, the presence of TIL was retrospectively evaluated in
RUFFINI, Enrico, ASIOLI, Sofia, FILOSSO, Pier Luigi, Lyberis P, Bruna MC, Macrì L, DANIELE, Lorenzo, OLIARO, Alberto   +7 more
openaire   +3 more sources

Immunotyping and Quantification of Melanoma Tumor–Infiltrating Lymphocytes

2021
The density of tumour-infiltrating lymphocytes (TILs) in melanoma is correlated with improved clinical prognosis; however, standardized TIL immunotyping and quantification protocols are lacking. Herein, we provide a review of the technologies being utilized for the immunotyping and quantification of melanoma TILs.
Zeyad T. Sahli, Max O. Meneveau, Craig L. Slingluff, Ileana S. Mauldin, Kevin T. Lynch   +4 more
openaire   +3 more sources

Tumor-infiltrating lymphocytes: A new hope

Cancer Cell
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik, Patrick, Hwu, James J, Mulé, Shari, Pilon-Thomas   +3 more
openaire   +2 more sources

Predictors of Tumor-Infiltrating Lymphocyte Efficacy in Melanoma

Immunotherapy, 2015
In the past decades, the increasing knowledge in cellular immunology and tumor-host immune interactions, led to the development of immunotherapy approaches. Immunotherapy, based on adoptive cell transfer of ex vivo activated and expanded tumor-infiltrating T lymphocytes (TILs), has shown promising clinical results in patients with metastatic melanoma ...
Michal J. Besser, Michal J. Besser, Jacob Schachter, Dragoslav Zikich   +3 more
openaire   +3 more sources

Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

Immunological Investigations, 1993
Tumor infiltrating lymphocytes (TIL) are increasingly employed in immunotherapy protocols. When modified and expanded they can be utilized in new therapeutic protocols. TIL augmentation can be in vitro and in vivo. The purpose of this article is to review the various methods of TIL augmentation and report our experience with a neoadjuvant technique of ...
M. Rubenstein, M. Shaw, P. Guinan
openaire   +3 more sources