Results 21 to 30 of about 135,956 (230)
Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
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Organ-on-a-chip Technology in Urology
Креативная хирургия и онкология, 2023 Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian +4 more
doaj +1 more source
Mechanical cues in tumor microenvironment on chip
Biosensors and Bioelectronics: X, 2023 Mechanical cues from the tumor microenvironment (TME) can influence cell behaviors and have been indicated to play a pivotal role in tumor initiation, progression, and metastasis. The integration of microfluidics technologies, bioelectronics, and tissue engineering approaches have allowed the development of various in-vitro TME on-chip models.
Zhiru Zhou +5 more
openaire +2 more sources
Analysis of Static Molecular Gradients in a High-Throughput Drug Screening Microfluidic Assay
Molecules, 2021 In this study, we thoroughly analyzed molecular gradient generation, its stability over time, and linearity in our high-throughput drug screening microfluidic assay (HTS).
Roman G. Szafran, Benita Wiatrak
doaj +1 more source
Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review. [PDF]
Int J Bioprint, 2022 The rising global incidence of cancer and high attrition rates of anticancer drugs make it imperative to design novel screening platforms to increase the success rate of chemotherapeutic agents. Advances in cell culture models from two-dimensional to three-dimensional platforms, along with microfluidics, have resulted in the creation of tumor-on-a-chip
Fang L, Liu Y, Qiu J, Wan W.
europepmc +3 more sources
Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine. [PDF]
Sci Adv, 2019 This colorectal tumor-on-chip model is an original and reliable platform for high-throughput drug screening and genetic expression.
Carvalho MR +7 more
europepmc +4 more sources
High‐Throughput Tumor‐on‐a‐Chip Platform to Study Tumor–Stroma Interactions and Drug Pharmacokinetics [PDF]
Advanced Healthcare Materials, 2020 Chun-Wei Chi, Bingmei Fu, Sihong Wang
exaly +2 more sources
Nano Convergence, 2021 Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology.
Jungeun Lim +4 more
doaj +1 more source
Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Biosensors, 2022 Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes of death worldwide. Due to the unclear molecular mechanism and complex in vivo microenvironment of tumors, it is challenging to reveal the
Xingxing Liu +10 more
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3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. [PDF]
Mol Cancer Ther, 2021 Abstract Disease models, including in vitro cell culture and animal models, have contributed significantly to developing diagnostics and treatments over the past several decades. The successes of traditional drug screening methods were generally hampered by not adequately mimicking critical in vivo features, such as a 3D ...
Wan L +6 more
europepmc +4 more sources