Results 31 to 40 of about 1,252,032 (285)

PDGFRα⁺/Integrin α2⁺ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano-Metabolic Symbiosis: E-Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer. [PDF]

Adv Sci (Weinh)
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Liu Y, Li J, Liu J, Dong Q, Zhang H, Wang Y, Li H, Guan Y, Cao L, Zhang M, Guo F, Liu X, Yang Z, Lu M, Liu H, Zhong L, Ji T, Liu T.   +17 more
europepmc   +2 more sources

The Prognostic Impact of Tumor Border Configuration, Tumor Budding and Tumor Stroma Ratio in Colorectal Carcinoma

Türk Patoloji Dergisi, 2023
Objective: Tumor border configuration, tumor budding and tumor stroma ratio are reliable histopathological parameters that play a central role in the invasion-metastasis cascade.
Lamia Sabry ABOELNASR, Hala Said EL-REBEY, Asmaa Shams El Dein MOHAMED, Asmaa Gaber ABDOU   +3 more
doaj   +1 more source

Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study. [PDF]

, 2021
Tumor budding has been reported to be an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Its use in daily diagnostics would improve the prognostic stratification of patients.
Lohneis, Philipp, Ramos Centeno, Irene, Zlobec, Inti, Insilla, Andrea Cacciato, Esposito, Irene, Wartenberg, Martin, Schaeffer, David F, Sempoux, Christine, Karamitopoulou, Evanthia, Kalloger, Steve, La Rosa, Stefano   +10 more
core   +2 more sources

The Significance of Tumor Budding and Immunohistochemical Axl Expression in Gallbladder Adenocarcinomas

Balkan Medical Journal, 2022
Background: Tumor budding is a histopathological finding that is accepted as an indicator of epithelial-mesenchymal transformation in many solid tumors.
Özden Öz, Asuman Argon, Tulu Kebat, Çisem Namlı Akıncı, Özlem Özdemir   +4 more
doaj   +1 more source

Evaluation of Tumour Budding in Head and Neck Squamous Cell Carcinoma and Its Relationship with other Histological Parameters of Prognosis

Asian Pacific Journal of Cancer Biology, 2023
Background: Tumor budding (TB) is an emerging and promising histopathological prognostic parameter in oral squamous cell carcinoma (SCC). Tumour budding shows positive correlation with lymph node metastasis, higher pattern of invasion, high grade of ...
Shreshtha Ghosh, Priyadarshini Guha
doaj   +1 more source

Association of Tumor Budding With Immune Evasion Pathways in Primary Colorectal Cancer and Patient-Derived Xenografts

Frontiers in Medicine, 2020
Tumor budding has been found to be of prognostic significance for several cancers, including colorectal cancer (CRC). Additionally, the molecular classification of CRC has led to the identification of different immune microenvironments linked to distinct
Silvia Guil-Luna, Silvia Guil-Luna, Rafael Mena, Carmen Navarrete-Sirvent, Laura María López-Sánchez, Laura María López-Sánchez, Karima Khouadri, Marta Toledano-Fonseca, Marta Toledano-Fonseca, Ana Mantrana, Ipek Guler, Carlos Villar, Cesar Díaz, Francisco Javier Medina-Fernández, Juan Rafael De la Haba-Rodríguez, Juan Rafael De la Haba-Rodríguez, Juan Rafael De la Haba-Rodríguez, Enrique Aranda, Enrique Aranda, Enrique Aranda, Enrique Aranda, Antonio Rodríguez-Ariza, Antonio Rodríguez-Ariza, Antonio Rodríguez-Ariza   +23 more
doaj   +1 more source

The prognostic value of tumor budding in gastric adenocarcinomas: A cross-sectional study

International Journal of Gastrointestinal Intervention, 2023
Background : : Tumor budding is a negative prognostic factor for many solid malignancies. We investigated the relationship between patients' clinicopathological characteristics and tumor budding, as well as the effect of budding level on prognosis ...
Tuba Baydas, Ganime Coban, Mehmet Besiroglu, Melih Simsek, Abdallah TM Shbair, Atakan Topcu, Ayse Irem Yasin, Mesut Seker, Haci Mehmet Turk   +8 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Alterations of membrane curvature during influenza virus budding [PDF]

, 2014
Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Martyna, Agnieszka, Rossman, Jeremy S.
core   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source