Results 251 to 260 of about 2,710,879 (342)

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Multimodal profiling of CAR T cells against glioblastoma using a microengineered 3D tumor-on-a-chip model. [PDF]

Bioact Mater
Ravi K, Trottier S, Amissah OB, Russell GC, Rho D, Kim GB, Nikkhah M.   +6 more
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Microgravity-cultured glioblastoma organoids integrated with microfluidic chip for CAR-γδ T evaluation. [PDF]

Commun Biol
Zhu G, Shi X, Jiang Y, Zhang W, Guo L, Pei G, Liu Y, Tang D, Wang C, Sun Z.   +9 more
europepmc   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer. [PDF]

Cell Biol Toxicol
Xu J, Zhang J, Li R, Chen S, Duan C, Ma X, Wang X, Liu X, Gu L, Meng K, Li M.   +10 more
europepmc   +1 more source

SOAT1 in ovarian cancer cells regulates immune response mediated by CD8⁺ T cells. [PDF]

J Ovarian Res
He J, Siu MKY, Long R, Hung L, Zhang R, Yung MMH, Lu H, Ngan HYS, Chan KKL.   +8 more
europepmc   +1 more source

Engineered macrophages accumulate in solid tumors and locally deliver immune-activating proteins to inhibit tumor progression. [PDF]

Transl Cancer Res
Xu Y, Zhou Y, Wang J.
europepmc   +1 more source