Results 21 to 30 of about 2,710,879 (342)

The action of ionizing irradiation alone or in combination with cisplatin on malignant cells: Investigations in vitro [PDF]

Archive of Oncology, 2003
The paper gives a brief review of the literature data based on in vitro investigations of cytotoxic action of cisplatin and irradiation, applied alone or in combination, to carcinoma cell lines and fresh tumor explants.
Juranić Zorica D., Čolaković Slobodanka, Sarić Milan, Čikarić Slobodan   +3 more
doaj   +1 more source

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]

, 2015
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P., Gronau, Julian H., King, Helen, Rodriguez-Teja, Mercedes, Shah, Neel, Sturge, Justin, Wang, Kai, Waxman, Jonathan   +7 more
core   +2 more sources

Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures [PDF]

Photochemistry and Photobiology, 2020
AbstractIn the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and T98G spheroids as shown by flow cytometry on the single cell level.
Grigalavicius, Mantas, Mastrangelopoulou, Maria, Arous, Delmon, Juzeniene, Asta, Ménard, Mathilde, Skarpen, Ellen, Berg, Kristian, Theodossiou, Theodossis A.   +7 more
openaire   +4 more sources

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity

Advances in Radiation Oncology, 2021
Purpose: Preclinical and clinical data indicate that radiation therapy acts as an immune modifier, having both immune-stimulatory and immunosuppressive effects on the tumor-immune microenvironment (TIME).
Lijun Li, MD, Renxiang Chen, PhD, Yun-Tien Lin, MS, Arslon Humayun, Albert J. Fornace, Jr., MD, Heng-Hong Li, PhD, MD   +5 more
doaj   +1 more source

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

Morphological Differences between Circulating Tumor Cells from Prostate Cancer Patients and Cultured Prostate Cancer Cells

PLoS ONE, 2014
Circulating tumor cell (CTC) enumeration promises to be an important predictor of clinical outcome for a range of cancers. Established CTC enumeration methods primarily rely on affinity capture of cell surface antigens, and have been criticized for ...
Sunyoung Park, Richard R Ang, S. Duffy, J. Bazov, K. Chi, P. Black, Hongshen Ma   +6 more
semanticscholar   +1 more source

Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors

Frontiers in Immunology, 2021
Cancer-associated fibroblasts (CAFs) has been recognized as one cause of tumor resistance to immune checkpoint blockade therapy, but the underlying mechanisms still remain elusive.
Tinglei Huang, Fuli Li, Xiaojiao Cheng, Jianzheng Wang, Wenhui Zhang, Baiwen Zhang, Yao Tang, Qingli Li, Cong Zhou, Shuiping Tu   +9 more
doaj   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources

Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

BMC Cancer, 2014
BackgroundTherapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerge, circulating tumor cells (CTCs ...
Glenn Deng, S. Krishnakumar, A. Powell, Haiyu Zhang, M. Mindrinos, M. Telli, Ronald W. Davis, S. Jeffrey   +7 more
semanticscholar   +1 more source