Results 51 to 60 of about 2,314,582 (300)

Influence of polyamine analogue DENSPM on cell growth of human SNB19 glioblastoma cells

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To investigate the influence of polyamine analogue DENSPM (N1, N11-diethylnorspermine) on cell growth of human SNB19 glioblastoma cells. Methods DENSPM was added into the culture medium of SNB19 cells. MTS assay was used to assess cell survival
Ye TIAN, Bin WANG, Shizhao WANG, Zhengjun WEI, Lin SUN, Rongcai JIANG, Jianning ZHANG   +6 more
doaj  

The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]

PLoS ONE, 2014
We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Yukihiko Hiroshima, Ali Maawy, Mohamed K Hassanein, Rhiana Menen, Masashi Momiyama, Takashi Murakami, Shinji Miwa, Mako Yamamoto, Fuminari Uehara, Shuya Yano, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Robert M Hoffman   +17 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Tumor ⁃ associated macrophages secrete TGFBI to promote malignancy of glioma stem cells in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To investigate the expression heterogeneity of transforming growth factor⁃β⁃induced protein (TGFBI) in glioblastoma (GBM) multiform and the mechanism of its promotion on malignancy of glioma stem cells (GSCs) in vitro.
Hong⁃tao ZHU, Dan LIU, Zi⁃rong CHEN, Ya⁃kun LI, Zhen WANG, Fang⁃ling CHENG, Jia⁃min LIU, Suo⁃jun ZHANG, Bin ZHANG, Feng WAN   +9 more
doaj  

Blue light irradiation inhibits the M2 polarization of the cancer-associated macrophages in colon cancer

BMC Cancer
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy.
Toshiaki Yoshimoto, Masaaki Nishi, Shohei Okikawa, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Chie Takasu, Hideya Kashihara, Yuma Wada, Takayuki Noma, Mitsuo Shimada   +10 more
doaj   +1 more source

3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity

Advances in Radiation Oncology, 2021
Purpose: Preclinical and clinical data indicate that radiation therapy acts as an immune modifier, having both immune-stimulatory and immunosuppressive effects on the tumor-immune microenvironment (TIME).
Lijun Li, MD, Renxiang Chen, PhD, Yun-Tien Lin, MS, Arslon Humayun, Albert J. Fornace, Jr., MD, Heng-Hong Li, PhD, MD   +5 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Tumor versus Stromal Cells in Culture—Survival of the Fittest?

PLoS ONE, 2013
Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for example, occurs in 40 to 50% of GBM, and yet, EGFR amplification is rarely preserved in cell cultures derived from human tumors.
Janice M. Nigro, Krishna M. Talasila, Marek Wagner, Kjersti Mangseth, Anja Torsvik, Hrvoje Miletic, Daniel Stieber, Narve Brekka, Lasse Evensen, Rolf Bjerkvig, Rupavathana Mahesparan, Simone P. Niclou, Olav Karsten Vintermyr, Gro V. Røsland   +13 more
openaire   +5 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Inhibiting effect of immunoeffector cells induced by denderitic cells vaccine on growth of PC3 and BEL7402

Journal of Acute Disease, 2018
Objective: To compare effect of immunoprevention or immunotherapy based on denderitic cells (DCs), or supernatants on pancreatic carcinoma and hepatocelluar carcinoma in vitro and in vivo.
Zao-Xi Sun, Zheng-Ke Sun, Kai Li, Ping Long, Ya-Chen Xu, Qiu-Xi Yang, Hai-Rong Huan, Cheng-Yi Sun   +7 more
doaj   +1 more source