Results 71 to 80 of about 2,314,582 (300)

Expression of PD-L1 on Monocytes Is a Novel Predictor of Prognosis in Natural Killer/T-Cell Lymphoma

Frontiers in Oncology, 2020
Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive lymphoma with a dismal prognosis, and novel therapeutic targets are urgently needed. Programmed death-ligand 1 (PD-L1) has become a promising therapeutic target for various cancers,
Xue-wen Zhang, Xue-wen Zhang, Xi-wen Bi, Xi-wen Bi, Pan-pan Liu, Pan-pan Liu, Ze-long Liu, Ze-long Liu, Man Nie, Man Nie, Hang Yang, Hang Yang, De-xin Lei, De-xin Lei, Yi Xia, Yi Xia, Wen-qi Jiang, Wen-qi Jiang, Wei-an Zeng, Wei-an Zeng   +19 more
doaj   +1 more source

Short-term serum-free culture reveals that inhibition of Gsk3β induces the tumor-like growth of mouse embryonic stem cells. [PDF]

PLoS ONE, 2011
Here, we present evidence that the tumor-like growth of mouse embryonic stem cells (mESCs) is suppressed by short-term serum-free culture, which is reversed by pharmacological inhibition of Gsk3β.
Yanzhen Li, Tamaki Yokohama-Tamaki, Tetsuya S Tanaka   +2 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Gelatin methacrylate hydrogels culture model for glioblastoma cells enriches for mesenchymal-like state and models interactions with immune cells

Scientific Reports, 2021
Glioblastoma is the most lethal primary malignant brain tumor in adults. Simplified two-dimensional (2D) cell culture and neurospheres in vitro models fail to recapitulate the complexity of the tumor microenvironment, limiting its ability to predict ...
Nameeta Shah, Pavan M. Hallur, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Komal Prasad Chandrachari, Ralph B. Puchalski, Aditya Chaubey   +7 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production

Biomedicines, 2020
Ambient temperature can regulate the immune response and affect tumor growth. Although thermoneutral caging reduces tumor growth via immune activation, little attention has been paid to the tumorigenic effect of low temperature.
Eun-Ji Lee, Tae-Wook Chung, Keuk-Jun Kim, Boram Bae, Bo-Sung Kim, Suhkmann Kim, Dongryeol Ryu, Sung-Jin Bae, Ki-Tae Ha   +8 more
doaj   +1 more source

Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer

Journal of experimental & clinical cancer research : CR, 2015
BackgroundDying tumor cells after irradiation could promote the proliferation of living tumor cells might cause tumor relapse and treatment failure.
Zhengxiang Zhang, Min Wang, Ling Zhou, Xiao Feng, Jin Cheng, Yang Yu, Yanping Gong, Yingwei Zhu, Chuan-Yuan Li, L. Tian, Qian Huang   +10 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

In Vitro Culture and Application of Circulating Tumor Cells

Zhongliu Fangzhi Yanjiu, 2018
Circulating tumor cells are formed by cancer cells in the primary or metastatic foci spreading to circulatory system, which is of great value in the early diagnosis of tumor, metastasis and recurrence monitoring and evaluation of efficacy, especially the important target of metastasis intervention.
Tian Jianhui, Shi Qihui, Qian Fangfang, Que Zujun, Dong Changsheng   +4 more
openaire   +3 more sources