Results 31 to 40 of about 1,368,638 (269)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Low-Level Laser Therapy Induces Melanoma Tumor Growth by Promoting Angiogenesis
Life, 2023 The effects of low-level laser therapy (LLLT) on tumor growth are inconsistent. In this study, we investigated the effects of LLLT on melanoma tumor growth and angiogenesis.
Yi-Yuan Lin, Shin-Yi Lee, Yu-Jung Cheng
doaj +1 more source
Effect of Colchicine on Tumor Growth and Tumor Pyrophosphatase
Experimental Biology and Medicine, 1951 Summary1. Treatment of a benzopyrene-induced rat sarcoma with colchicine produced tumor regression. This regression was complete in some cases. 2. No hemorrhage has been observed in tumors treated with colchicine. 3. This tumor contains a potent enzyme capable of hydrolysing sodium pyrophosphate. 4. The pyrophosphatase of tumors treated with colchicine
L, BLOCH-FRANKENTHAL, A, BACK
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis
Frontiers in Pharmacology, 2019 Esophagus cancer is the seventh cause of cancer-related deaths globally. In this study, we analyzed interleukin 6 (IL-6) gene expression in human esophagus cancer patients and showed that IL-6 mRNA levels are significantly higher in tumor tissues and ...
Jian-Ge Qiu +14 more
doaj +1 more source
Optimal Control and Parameters Identification for the Cahn–Hilliard Equations Modeling Tumor Growth
Mathematics, 2023 This paper is dedicated to the setting and analysis of an optimal control problem for a two-phase system composed of two non-linearly coupled Chan–Hilliard-type equations.
Mostafa Kadiri +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Cancer Medicine, 2013 Transcription factor Slug/SNAI2 (snail homolog 2) plays a key role in the induction of the epithelial mesenchymal transition in cancer cells; however, whether the overexpression of Slug mediates the malignant phenotype and alters drug sensitivity in lung
Daisuke Tamura +18 more
doaj +1 more source
Vascular co-option in resistance to anti-angiogenic therapy
Frontiers in Oncology, 2023 Three different mechanisms of neovascularization have been described in tumor growth, including sprouting angiogenesis, intussusceptive microvascular growth and glomeruloid vascular proliferation.
Domenico Ribatti +3 more
doaj +1 more source