Results 11 to 20 of about 1,368,638 (269)

Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Cancer Cell International, 2023
Background In vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs. Among these in vivo experimental models, the establishment of highly malignancy cell lines with xenograft ...
Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro Semba   +8 more
doaj   +1 more source

Novel kinase-activating genetic events in non-small cell lung carcinomas [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: This study aimed at the identification of new druggable alterations in non-small cell lung carcinomas (NSCLCs). Methods: RNA next generation sequencing (NGS) analysis for 650 protein kinase genes was performed for 89 NSCLCs obtained from young-onset
Elena V. Preobrazhenskaya, Rimma S. Mulkidjan, Fyodor A. Zagrebin, Alexandr A. Romanko, Evgeniya S. Saitova, Polina R. Korzun, Jeyla O. Binnatova, Vladislav I. Tiurin, Ilya V. Bizin, Evgeny N. Imyanitov   +9 more
doaj   +1 more source

PDK4 Constitutes a Novel Prognostic Biomarker and Therapeutic Target in Gastric Cancer

Diagnostics, 2022
Gastric cancer (GC) is one of the most prevalent and deadly malignancies worldwide. We aimed to assess the functional role and clinical significance of pyruvate dehydrogenase kinase (PDK) in GC and explored the underlying mechanisms.
Zimu Zhang, Shiyuan Han, Siwen Ouyang, Ziyang Zeng, Zhen Liu, Juan Sun, Weiming Kang   +6 more
doaj   +1 more source

Overview on biomarkers for immune oncology drugs [PDF]

Exploration of Targeted Anti-tumor Therapy
Although immune checkpoint inhibitors (ICIs) are widely used in clinical oncology, less than half of treated cancer patients derive benefit from this therapy. Both tumor- and host-related variables are implicated in response to ICIs. The predictive value
Evgeny N. Imyanitov, Elena V. Preobrazhenskaya, Natalia V. Mitiushkina   +2 more
doaj   +1 more source

Improvement of the sensitivity of circulating tumor DNA-based liquid biopsy: current approaches and future perspectives [PDF]

Exploration of Targeted Anti-tumor Therapy
Liquid biopsy (LB) is a complex of procedures aimed at the detection of tumor-derived fragments (nucleic acids, proteins, cells, etc.) persisting in the blood or other body fluids.
Ekaterina S. Kuligina, Grigoriy A. Yanus, Evgeny N. Imyanitov   +2 more
doaj   +1 more source

Molecular diagnostics in clinical oncology: an overview [PDF]

Exploration of Medicine
Molecular diagnostics has become an integral part of modern clinical oncology. There are several dozen hereditary cancer syndromes; the detection of germline pathogenic variants in tumor-predisposing genes allows for the identification of subjects at ...
Evgeny Imyanitov, Anna Sokolenko
doaj   +1 more source

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth [PDF]

Cell Reports, 2016
The known link between obesity and cancer suggests an important interaction between the host lipid metabolism and tumorigenesis. Here, we used a syngeneic tumor graft model to demonstrate that tumor development influences the host lipid metabolism.
Jianfeng Huang, Lena Li, Jihong Lian, Silvia Schauer, Paul W. Vesely, Dagmar Kratky, Gerald Hoefler, Richard Lehner   +7 more
openaire   +3 more sources

Molecular Diagnostics in Clinical Oncology

Frontiers in Molecular Biosciences, 2018
There are multiple applications of molecular tests in clinical oncology. Mutation analysis is now routinely utilized for the diagnosis of hereditary cancer syndromes.
Anna P. Sokolenko, Anna P. Sokolenko, Evgeny N. Imyanitov, Evgeny N. Imyanitov, Evgeny N. Imyanitov, Evgeny N. Imyanitov   +5 more
doaj   +1 more source

DIET AND TUMOR GROWTH [PDF]

Journal of Experimental Medicine, 1915
Lactose does not increase the receptivity of mice and rats for the transplantable carcinomata of their species.
openaire   +2 more sources

Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment

Frontiers in Physiology, 2018
Axon guidance molecules play an important role in regulating proper neuronal networking during neuronal development. They also have non-neuronal properties, which include angiogenesis, inflammation, and tumor development. Semaphorin 3F (SEMA3F), a member
Hironao Nakayama, Hironao Nakayama, Chiaki Kusumoto, Masako Nakahara, Akira Fujiwara, Shigeki Higashiyama   +5 more
doaj   +1 more source