Results 1 to 10 of about 1,368,638 (269)
Molecular Analysis of Biliary Tract Cancers with the Custom 3′ RACE-Based NGS Panel
Diagnostics, 2023 The technique 3’ rapid amplification of cDNA ends (3′ RACE) allows for detection of translocations with unknown gene partners located at the 3′ end of the chimeric transcript.
Natalia V. Mitiushkina +11 more
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Cancer Medicine, 2022 Background Despite the progress in the development of next‐generation sequencing (NGS), diagnostic PCR assays remain to be utilized in clinical routine due to their simplicity and low cost.
Natalia V. Mitiushkina +15 more
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Exploration of Targeted Anti-tumor Therapy, 2023 Early clinical trials aimed to halt cancer progression by inhibiting the growth of new blood vessels in tumors through single-agent targeted therapy with bevacizumab. These trials largely proved unsuccessful.
Alexey V. Emshanov +4 more
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Cancer Medicine, 2023 Coding sequences of BRCA1, BRCA2, ATM, TP53, and PALB2 genes were analyzed in 68 consecutive Chechen patients with high‐grade serous ovarian cancer (HGSOC). Pathogenic BRCA1/2 variants were identified in 15 (22%) out of 68 HGSOC cases.
Anna P. Sokolenko +16 more
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OncoImmunology, 2012 We have investigated the role of the Ca(2+)-binding protein S100A9 on tumor growth in prostate cancer and T-cell lymphoma models. We found that the expression of, S100A9 and its interaction with Toll-like receptor 4 (TLR4) is critical for tumor growth in these settings.
Leanderson, Tomas, Ivars, Fredrik
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Hyaluronan and Tumor Growth [PDF]
The American Journal of Pathology, 2002 The study published in this issue of The American Journal of Pathology by Simpson et al 1 adds a new dimension to the role of hyaluronan in cancer by demonstrating that inhibition of endogenous hyaluronan synthesis dramatically reduces tumor growth in vivo.
Bryan P, Toole, Vincent C, Hascall
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Tumor Growth with Nutrients: Stability of the Tumor Patches
SIAM Journal on Mathematical Analysis, 2023 In this paper, we study a tumor growth model with nutrients. The contact inhibition for the tumor cells, presented in the model, results in the evolution of a congested tumor patch. We study the regularity of the tumor patch as the nutrients' diffusion strength $D$ diminishes.
Inwon Kim, Jona Lelmi
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Harmonization of Molecular Testing for Non-Small Cell Lung Cancer: Emphasis on PD-L1
Frontiers in Oncology, 2020 Comprehensive molecular testing plays a critical role in the choice of treatment for non-small lung cell cancer (NSCLC). The analysis of druggable alterations in EGFR, BRAF, MET, KRAS, ALK, ROS1, RET and NTRK1/2/3 genes is more or less standardized and ...
Evgeny N. Imyanitov +4 more
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Platinum drugs and taxanes: can we overcome resistance?
Cell Death Discovery, 2021 Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell proliferation and induction of cell death. Many research publications discussing the mechanisms of anticancer drugs use the terms “cell death” and “apoptosis ...
Elena V. Sazonova +3 more
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Comparison of outcomes of neoadjuvant chemotherapy in BRCA1- versus BRCA2-associated breast and ovarian cancers [PDF]
Exploration of Targeted Anti-tumor TherapyAim: BRCA1/2-associated breast and ovarian carcinomas are often regarded as a single entity, assuming that BRCA1 and BRCA2 genes are almost equivalent with regard to their clinical significance.
Anna Sokolenko +9 more
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