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Recent Advances in the Application of Nitro(het)aromatic Compounds for Treating and/or Fluorescent Imaging of Tumor Hypoxia. [PDF]

Molecules
Anichina K, Lumov N, Bakov V, Yancheva D, Georgiev N.   +4 more
europepmc   +1 more source

Investigating the effects of stereotactic body radiation therapy on pancreatic tumor hypoxia and microvasculature in an orthotopic mouse model using intravital fluorescence microscopy. [PDF]

Sci Rep
Samuel T, Rapic S, Lindsay PE, DaCosta RS.   +3 more
europepmc   +1 more source

Tracing tumor hypoxia

, 2019
Vooijs, M, Ient, J, Groot, A, Vermeer, J, Muschel, R, Van Rheenen, J, Postrach, D, Markelc, B   +7 more
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Tumor Hypoxia Imaging

Molecular Imaging and Biology, 2010
There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and predicting the outcome of therapy. A number of invasive and noninvasive techniques have been exploited to measure tumor hypoxia, including polarographic needle electrodes, immunohistochemical staining, radionuclide imaging (positron emission tomography [PET] and ...
Xilin, Sun, Gang, Niu, Nicholas, Chan, Baozhong, Shen, Xiaoyuan, Chen   +4 more
openaire   +2 more sources

Hypoxia and the Tumor Secretome

2019
Metastasis remains the leading cause of cancer-related deaths. To date, there are no specific treatments targeting disseminated disease. New therapeutic options will become available only if we enhance our understanding of mechanisms underlying metastatic spread.
Ying, Liu, Gabrielle E, Ciotti, T S Karin, Eisinger-Mathason   +2 more
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Hypoxia and hypoxia inducible factors in tumor metabolism

Cancer Letters, 2015
Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting ...
Wen, Zeng, Peiyi, Liu, Weimin, Pan, Shree Ram, Singh, Yiyong, Wei   +4 more
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Imaging hypoxia in tumors

Seminars in Nuclear Medicine, 2001
For many years, it has been known that hypoxia affects the response to radiotherapy in human cancers. Hypoxic regions can develop as a tumor grows beyond the ability of its blood supply to deliver oxygen to the full extent of the tumor, exacerbated by vascular spasm or compression caused by increased interstitial fluid pressure.
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Hypoxia-inducible factors, hypoxia, and tumor angiogenesis

Current Opinion in Hematology, 2006
The transcription factor hypoxia-inducible factor is activated by low oxygen to promote the expression of target genes that allow cellular, tissue, and organismal adaptation to low oxygen. Hypoxia-inducible factor is activated not only by hypoxia but also as a consequence of genetic mutations in a variety of tumors.
Michaela, Gruber, M Celeste, Simon
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Imaging hypoxia and angiogenesis in tumors

Radiologic Clinics of North America, 2005
There is a clear need in cancer treatment for a noninvasive imaging assay that evaluates the oxygenation status and heterogeneity of hypoxia and angiogenesis in individual patients. Such an assay could be used to select alternative treatments and to monitor the effects of treatment.
Joseph G, Rajendran, Kenneth A, Krohn
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Hypoxia imaging in brain tumors

Neuroimaging Clinics of North America, 2002
Assessment of the oxygenation status of brain tumors has been studied increasingly with imaging techniques in light of recent advances in oncology. Tumor oxygen tension is a critical factor influencing the effectiveness of radiation and chemotherapy and malignant progression.
F Zerrin, Yetkin, Dianne, Mendelsohn
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