Results 261 to 270 of about 1,922,670 (308)
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2014
Cells that survive oxygen deprivation (hypoxia) are known to be resistant to radiation therapy. Numerous approaches have been developed to deal with this hypoxia-induced radioresistance. They include increasing tumor oxygen delivery, chemically radiosensitizing the hypoxic cells, or killing them with specific cytotoxins.
Nordsmark, M. +5 more
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Cells that survive oxygen deprivation (hypoxia) are known to be resistant to radiation therapy. Numerous approaches have been developed to deal with this hypoxia-induced radioresistance. They include increasing tumor oxygen delivery, chemically radiosensitizing the hypoxic cells, or killing them with specific cytotoxins.
Nordsmark, M. +5 more
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Tumor hypoxia and cancer progression
Cancer Letters, 2006Aerobic life consumes oxygen for efficient production of high energy compounds. The ability to sense and respond to changes in oxygen partial pressure represents a fundamental property to assure the cellular oxygen supply to be within a narrow range that balances the risks of oxidative damage vs. oxygen deficiency.
Jie, Zhou +3 more
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Effects of hypoxia on tumor metabolism
Cancer and Metastasis Reviews, 2007Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells.
Jung-whan, Kim, Ping, Gao, Chi V, Dang
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Hypoxia and the Radiation Response of Tumors
1983The effect of hypoxia on the in vivo radiation response of tumors is demonstrated both for the measurement of cell survival and growth delay following treatment. Results using these endpoints for the KHT Sarcoma are then presented to demonstrate the effect of various parameters which are expected to control tumor oxygenation: blood flow, blood pO2 ...
R P, Hill, M G, Pallavicini
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Tumor Hypoxia and Malignant Progression
2004Publisher Summary This chapter discusses tumor hypoxia and malignant progression. Hypoxic (or anoxic) areas arise as a result of an imbalance between the supply and the consumption of oxygen. Whereas in normal tissues or organs the O2 supply matches the metabolic requirements, in locally advanced solid tumors the O2 consumption rate of neoplastic as ...
Peter, Vaupel +2 more
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Seminars in Radiation Oncology, 1996
A variety of techniques for measuring oxygen in normal and tumor tissue has been developed over the years in response to the realization that hypoxia is important in a number of pathophysiological conditions in normal tissues and in the response of tumors to radiation treatment.
James A. Raleigh +2 more
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A variety of techniques for measuring oxygen in normal and tumor tissue has been developed over the years in response to the realization that hypoxia is important in a number of pathophysiological conditions in normal tissues and in the response of tumors to radiation treatment.
James A. Raleigh +2 more
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Neurosurgery Quarterly, 2009
Primary malignant brain tumors are estimated to have caused more than 12,800 deaths in the United States in 2006, and nearly 19,000 new cases are diagnosed annually in this country. The glial-derived neoplasm, or glioma, is the most aggressive type of brain tumor and accounts for 44% of all primary brain tumors.
Nathan J. Ranalli +2 more
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Primary malignant brain tumors are estimated to have caused more than 12,800 deaths in the United States in 2006, and nearly 19,000 new cases are diagnosed annually in this country. The glial-derived neoplasm, or glioma, is the most aggressive type of brain tumor and accounts for 44% of all primary brain tumors.
Nathan J. Ranalli +2 more
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2020
Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The development of tumor hypoxia can be viewed as an imbalance between oxygen supply and demand. Tumor hypoxia significantly impacts tumor radiosensitivity and subsequently leads to poor clinical outcomes in patients treated with radiation therapy.
Michael Skwarski +4 more
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Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The development of tumor hypoxia can be viewed as an imbalance between oxygen supply and demand. Tumor hypoxia significantly impacts tumor radiosensitivity and subsequently leads to poor clinical outcomes in patients treated with radiation therapy.
Michael Skwarski +4 more
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Tumor Hypoxia in Cancer Therapy
2007Human solid tumors are invariably less well-oxygenated than the normal tissues from which they arose. This so-called tumor hypoxia leads to resistance to radiotherapy and anticancer chemotherapy as well as predisposing for increased tumor metastases.
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The Lung-to-Tumor Interface for the Evaluation of Tumor Hypoxia
Radiology, 2022David J. Murphy, David T. Ryan
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