Results 11 to 20 of about 443,774 (290)

Tumor Immunology and Immunotherapy of Non-Small-Cell Lung Cancer. [PDF]

open access: greenCold Spring Harb Perspect Med, 2022
Cascone T   +3 more
europepmc   +3 more sources

KLF4-mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP

open access: yesCell Communication and Signaling, 2023
The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (
Reem Alkhayer   +6 more
doaj   +1 more source

NKG2D and its ligands: one for all, all for one [PDF]

open access: yes, 2018
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Cerboni, Cristina   +7 more
core   +11 more sources

Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors

open access: yesOncoImmunology, 2023
The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the systemic immune
Olga S. Blomberg   +15 more
doaj   +1 more source

Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity

open access: yesJournal of Immunology Research, 2023
Objective. The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) has recently gained attention. Costimulatory molecules are membrane proteins strictly associated with T-cell receptor (TCR), acting by activating or inhibiting T ...
Fulvia Ceccarelli   +8 more
doaj   +1 more source

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