Results 41 to 50 of about 438,171 (330)

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities [PDF]

, 2019
Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the ...
Botti L., Cappetti B., Chiodoni C., Colombo M. P., Consonni F. M., Gulino A., Nicola M. D., Portararo P., Randon G., Sangaletti S., Sica A., Talarico G., Tripodo C.   +12 more
core   +3 more sources

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

A review on tumor immunology

Journal of Orofacial Sciences, 2017
The ability of immune system to detect and destroy the altered/abnormal cells may inhibit the development of various cancers. The immune system had been proposed as a tactic in sustaining nonneoplastic state and also for the development of immunotherapy ...
Sri Lalitha Kaja, S. V. N. Sasi Kiran, Kiran Kumar Kattapagari, Ravi Teja Chitturi, S Deepika Chowdary, Baddam Venkata Ramana Reddy   +5 more
doaj   +1 more source

Isolation of native EVs from primary biofluids—Free‐flow electrophoresis as a novel approach to purify ascites‐derived EVs

Journal of Extracellular Biology, 2022
Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain challenging. Here we introduce free‐flow electrophoresis (FFE) as a novel approach for purifying EVs from
Christian Preußer, Kathrin Stelter, Tobias Tertel, Manuel Linder, Frederik Helmprobst, Witold Szymanski, Johannes Graumann, Bernd Giebel, Silke Reinartz, Rolf Müller, Gerhard Weber, Elke Pogge vonStrandmann   +11 more
doaj   +1 more source

Immunologic Treatment of Tumors.

Experimental Biology and Medicine, 1959
SummaryWe produced antibodies by injecting cancer cells obtained from Walker 256 tumor into rabbits; after several injections of the cell antigen, the rabbits were exsanguinated, and the serum fractionated. Antibodies to normal tissue were adsorbed out by exposure to normal tissue.
J A, McCREDIE, E R, BROWN, W H, COLE
openaire   +2 more sources

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Clonal expansion shapes the human V\u3b41T cell receptor repertoire. [PDF]

, 2017
Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not ...
Dieli, F., Meraviglia, S.
core   +1 more source

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

CART cells are prone to Fas- and DR5-mediated cell death

Journal for ImmunoTherapy of Cancer, 2018
Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that
Benjamin O. Tschumi, Nina Dumauthioz, Bastien Marti, Lianjun Zhang, Pascal Schneider, Jean-Pierre Mach, Pedro Romero, Alena Donda   +7 more
doaj   +1 more source

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

Cancer Cell International, 2022
Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han, Lixin Wei   +8 more
doaj   +1 more source