Results 11 to 20 of about 267,145 (352)
Tumor-infiltrating lymphocytes for melanoma immunotherapy
Oliver Kepp+3 more
doaj +4 more sources
Tumor-infiltrating lymphocytes in the immunotherapy era [PDF]
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell, NK cell, and more recently, B cell responses within the tumor microenvironment.
S. Paijens+3 more
semanticscholar +4 more sources
Role of tumor-infiltrating lymphocytes in melanoma
Yasemin Benderli Cihan
doaj +2 more sources
Tumor Infiltrating Lymphocytes in Ovarian Cancer [PDF]
Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates. In this scenario, a pivotal role has been endorsed to the immunological environment and to the immunological mechanisms ...
GASPARRI, MARIALUISA+8 more
openaire +8 more sources
Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors [PDF]
AbstractTumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in ...
Zicheng Yu+10 more
openaire +4 more sources
Tumor-Infiltrating Lymphocytes in Melanoma [PDF]
Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is arguably the most effective treatment for patients with metastatic melanoma. With higher response rates than ipilimumab or IL-2, and longer durations of response than vemurafenib, TIL therapy carries the potential to transform current outcomes in melanoma, while also defining the way ...
Sylvia Lee+3 more
openaire +3 more sources
Tumor infiltrating lymphocytes and radiological picture of the tumor
AbstractTumor microenvironment (TME) is a complex entity that includes besides the tumor cells also a whole range of immune cells. Among various populations of immune cells infiltrating the tumor, tumor infiltrating lymphocytes (TILs) are a population of lymphocytes characterized by high reactivity against the tumor component.
Karolina Frankowska+3 more
openaire +2 more sources
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma [PDF]
Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these patients will not have a durable benefit. Phase 1-2 trials of adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) have shown promising responses, but data from phase 3 trials are lacking ...
Maartje W. Rohaan+56 more
openaire +10 more sources
Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses.
Hilde Haave+7 more
doaj +1 more source
The biologic importance of tumor‐infiltrating lymphocytes [PDF]
Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F. Stephen Hodi, Glenn Dranoff
openaire +2 more sources