Results 11 to 20 of about 343,340 (395)

The role of tumor-infiltrating lymphocytes in cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Cholangiocarcinoma (CCA) is the second most common primary liver cancer and associated with a dismal prognosis due to the lack of an efficient systemic therapy. In contrast to other cancers, new immunotherapies have demonstrated unsatisfactory results in
Dong Liu, Lara Rosaline Heij, Zoltan Czigany, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch   +8 more
doaj   +2 more sources

Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer

JAMA Oncology, 2023
Key Points Question Which immune-related biomarker provides the most valuable information to predict pathologic complete response and event-free survival in patients with early-stage ERBB2/HER2-positive breast cancer: tumor-infiltrating lymphocytes ...
A. Fernández-Martínez, T. Pascual, Baljit Singh, P. Nuciforo, N. Rashid, K. Ballman, J. Campbell, K. Hoadley, P. Spears, L. Paré, F. Brasó-Maristany, N. Chic, I. Krop, A. Partridge, J. Cortés, A. Llombart-Cussac, A. Prat, C. Perou, L. Carey   +18 more
semanticscholar   +1 more source

Tumor-Infiltrating Lymphocytes in Colorectal Cancer: The Fundamental Indication and Application on Immunotherapy

Frontiers in Immunology, 2022
The clinical success of immunotherapy has revolutionized the treatment of cancer patients, bringing renewed attention to tumor-infiltrating lymphocytes (TILs) of various cancer types.
Ziyi Bai, Yao Zhou, Zi-Dan Ye, Jialong Xiong, Hongying Lan, Feng Wang   +5 more
semanticscholar   +1 more source

Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?

Frontiers in Immunology, 2022
Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are recruited into the tumor site to fight against tumors. However, their small number and reduced activity limit their ability to overcome the tumor. Enhancement of
M. Kazemi, M. Sadri, A. Najafi, A. Rahimi, Zeinab Baghernejadan, H. Khorramdelazad, R. Falak   +6 more
semanticscholar   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression

Cancers, 2022
Simple Summary The assessment of tumor-infiltrating lymphocytes (TILs) is gaining acceptance as a robust biomarker to help predict prognosis and treatment response.
Danielle Fassler, L. Torre-Healy, Rajarsi R. Gupta, Alina M. Hamilton, Soma Kobayashi, Sarah C. Van Alsten, Yuwei Zhang, T. Kurç, R. Moffitt, M. Troester, K. Hoadley, J. Saltz   +11 more
semanticscholar   +1 more source

Tumor Infiltrating Lymphocytes in Ovarian Cancer [PDF]

Asian Pacific Journal of Cancer Prevention, 2015
Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates. In this scenario, a pivotal role has been endorsed to the immunological environment and to the immunological mechanisms ...
GASPARRI, MARIALUISA, Attar, R, PALAIA, INNOCENZA, PERNIOLA, GIORGIA, Marchetti, C, DI DONATO, VIOLANTE, Farooqi, Aa, Papadia, A, BENEDETTI PANICI, PIERLUIGI   +8 more
openaire   +7 more sources

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +5 more sources

CD8+ T-cell lymphocytes infiltration predict clinical outcomes in Wilms’ tumor

Tumor Biology, 2020
The abundance and location of CD8+ tumor-infiltrating lymphocytes demonstrate important facets of the anticancer immune response. CD8-expressing lymphocytes have been used in immunotherapy for multiple cancers.
Keykhosro Mardanpour, Mahtab Rahbar, Sourena Mardanpour, Nyousha Mardanpour, Mansour Rezaei   +4 more
doaj   +1 more source

Tumor Infiltrating Lymphocytes-N2-Transduced [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources