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The biologic importance of tumor‐infiltrating lymphocytes [PDF]
Journal of Cutaneous Pathology, 2010 Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F Stephen, Hodi, Glenn, Dranoff
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Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors [PDF]
BMC Medicine, 2021 AbstractTumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in ...
Shuhang Wang +10 more
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Zhongguo aizheng zazhi, 2021 Background and purpose: Programmed death 1 (PD-1) plays an important role in the regulation of peripheral immune tolerance. The expression of PD-1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma (HCC) and the relationship between PD-1 ...
肖 锋 +4 more
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Association between tumor-infiltrating lymphocytes and sentinel lymph node positivity in thin melanoma [PDF]
Anais Brasileiros de Dermatologia, 2019 : Background: Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this ...
Fernando De Marco dos Santos +5 more
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Tumor-infiltrating lymphocytes for adoptive cell therapy
, 2022 Disclosed are compositions and methods for ex vivo expansion of tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor-infiltrating ...
Liu, Hao +3 more
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Frontiers in Immunology, 2023 IntroductionTumor-infiltrating T lymphocytes in the tumor microenvironment are critical factors influencing the prognosis and chemotherapy outcomes. As a Chinese herbal medicine, Marsdenia tenacissima extract (MTE) has been widely used to treat cancer in
Ben Yi +15 more
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The International Journal of Biological Markers, 2019 Purpose: This study aimed to elucidate the clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer. Methods: The immunohistochemistry of CD3 and CD8 was performed on 265 human colorectal cancer tissues ...
Young San Ko, Jung-Soo Pyo
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Cellular Physiology and Biochemistry, 2017 Background/Aims: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human ...
Yun Xu +9 more
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CTL Attenuation Regulated by PS1 in Cancer-Associated Fibroblast
Frontiers in Immunology, 2020 Objective: Cancer-associated fibroblasts (CAFs) were associated with tumor progression in the tumor microenvironment (TME). However, their immunosuppressive roles in protecting cancer cells from the attack by cytotoxic T lymphocytes (CTLs) are not fully ...
Hongyu Zhang +23 more
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OncoImmunology, 2021 The interaction of CNS tumors with infiltrating lymphocytes plays an important role in their initiation and progression and might be related to therapeutic responses.
Sepehr Safaei +4 more
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