Results 271 to 280 of about 267,145 (352)

A Dynamic Contrast‐Enhanced MRI‐Based Vision Transformer Model for Distinguishing HER2‐Zero, ‐Low, and ‐Positive Expression in Breast Cancer and Exploring Model Interpretability

Advanced Science, EarlyView.
This study develops a Vision Transformer‐based DCE‐MRI model for the non‐invasive classification of HER2 expression in breast cancer, demonstrating robust performance across multicenter cohorts. By integrating transcriptomic analysis, the model reveals immune‐related pathway differences among distinct HER2 expression levels.
Xu Zhang, Yi‐Yuan Shen, Guan‐Hua Su, Yuan Guo, Ren‐Cheng Zheng, Si‐Yao Du, Si‐Yi Chen, Yi Xiao, Zhi‐Ming Shao, Li‐Na Zhang, He Wang, Yi‐Zhou Jiang, Ya‐Jia Gu, Chao You   +13 more
wiley   +1 more source

Combined Tumor Infiltrating Lymphocytes and PD-L1 Status in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma. [PDF]

Head Neck
Haring CT, Smith JD, Dermody SM, McHugh JB, Perry WR, Brummel C, Spector ME, Brenner JC, Swiecicki PL.   +8 more
europepmc   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

AI-detected tumor-infiltrating lymphocytes for predicting outcomes in anti-PD1 based treated melanoma

Schuiveling M, van Duin IA, Maat Lt, van der Weerd JC, Verheijden RJ, van den Berkmortel F, Blank CU, Breimer GE, Burgers FH, Boers-Sonderen M, van den Eertwegh AJM, de Groot JWB, Haanen JB, Hospers GA, Kapiteijn E, Piersma D, Vreugdenhil G, Westgeest H, Schrader AM, Pluim J, van Diest PJ, Veta M, Suijkerbuijk KP, Blokx W.   +23 more
europepmc   +1 more source

Constructing a neural network model based on tumor-infiltrating lymphocytes (TILs) to predict the survival of hepatocellular carcinoma patients. [PDF]

PeerJ
Zhong W, Zhao Z, Fang X, Sun J, Wei Y, Li F, Han B, Jin C.   +7 more
europepmc   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

High Tumoral CD24 Expression and Low CD3⁺ Tumor-Infiltrating Lymphocytes as a Biomarker for High-Risk Locally Advanced Nasopharyngeal Carcinoma. [PDF]

Cancers (Basel)
Ghebeh H, Mirza JY, Mohammed SF, Khoja HA, Dababo MA, Tukruni ME, Anwar MS, Aldehaim M, Al-Rajhi N.   +8 more
europepmc   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Tumor-infiltrating lymphocytes in HER2-positive breast cancer: potential impact and challenges. [PDF]

ESMO Open
Schlam I, Loi S, Salgado R, Swain SM.
europepmc   +1 more source

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

Advanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang, Wen‐Chi Xue, Chao Liang, Pan Liu, Yao Lei, Jiaqi He, Ran Cheng, Weidong Nie, Jianxiong Wang, Jie Tang, Hai‐Yan Xie   +10 more
wiley   +1 more source