Results 271 to 280 of about 343,340 (395)

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Tumor-infiltrating lymphocytes and tumor-associated macrophages in cancer immunoediting: a targetable therapeutic axis. [PDF]

Front Immunol
Mukherjee S, Ghosh A, Chakraborty S, Basak U, Mukherjee S, Das T, Sa G.   +6 more
europepmc   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

918 Functional heterogeneity of CD4+ tumor-infiltrating lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Marco Donia, Mads H Andersen, Martin Lauss, Göran Jönsson, Arianna Draghi, Katja Harbst, Inge Svane, Torben Lorentzen, Shawez Khan, Mario Presti, Christopher A Chamberlain, Agnete WP Jensen, Michael D Crowther, Anne-Christine K Rasmussen, Benedetta Albieri   +14 more
doaj   +1 more source

Prognostic value of visually and computationally assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030). [PDF]

J Natl Cancer Inst
Nader-Marta G, Chu X, Mukhopadhyay S, Abramson VG, Brufsky A, Stringer-Reasor EM, Dent SF, Traina TA, Carey LA, Rimawi MF, Specht JM, Miller KD, Santa-Maria CA, Dasgupta T, Kurt BB, DeMeo M, Krop IE, Tung NM, Schnitt SJ, Tayob N, Mayer EL.   +20 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Tumor-Infiltrating Lymphocytes Predict Extranodal Extension and Prognosis in Regionally Advanced Oral Cavity Cancer. [PDF]

Diagnostics (Basel)
Lorencin Bulic M, Jurlina M, Müller D, Lijovic L, Mamic M, Luksic I.   +5 more
europepmc   +1 more source

660 A phase 1/2 study of KSQ-001EX: an autologous tumor-infiltrating lymphocyte therapy engineered to inactivate theSOCS1gene in patients with select advanced solid tumors [PDF]

Rodabe N. Amaria, Michael A. Davies, Alexandra P. Ikeguchi, Jennifer L. McQuade, Adi Diab, Hussein A. Tawbi, Isabella C. Glitza, Youlia Petrova, Katelynn Oliver, Khaled Sanber, George Blumenschein, Mehmet Altan, Cara Haymaker, Chantale Bernatchez, Marie‐Andrée Forget, Ivy Lai, Joanne Shaw, Erica R. Tobin, Micah J. Benson, Karrie Wong, Patricia M. Harris   +20 more
openalex   +1 more source

Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

JAMA Oncology, 2017
E. Goode, M. Block, K. Kalli, R. Vierkant, Wenqian Chen, Z. Fogarty, A. Gentry-Maharaj, A. Tołoczko, A. Hein, Aliecia L. Bouligny, A. Jensen, A. Osorio, A. Hartkopf, A. Ryan, A. Chudecka-Głaz, A. Magliocco, A. Hartmann, A. Jung, B. Gao, B. Hernandez, B. Fridley, Bryan M McCauley, C. Kennedy, Chen Wang, C. Karpinskyj, C. B. de Sousa, D. Tiezzi, D. Wachter, E. Herpel, F. Taran, F. Modugno, G. Nelson, J. Lubiński, J. Menkiszak, J. Alsop, J. Lester, J. García-Donas, J. Nation, J. Hung, J. Palacios, J. Rothstein, J. Kelley, J. M. de Andrade, L. Robles-Díaz, M. Intermaggio, M. Widschwendter, M. Beckmann, M. Ruebner, M. Jimenez-Linan, N. Singh, O. Oszurek, P. Harnett, P. Rambau, P. Sinn, Philipp Wagner, P. Ghatage, Raghwa N. Sharma, R. Edwards, R. Ness, S. Orsulic, S. Brucker, S. Johnatty, T. Longacre, U. Eilber, V. McGuire, W. Sieh, Y. Natanzon, Zheng Li, A. Whittemore, A. Defazio, A. Staebler, B. Karlan, B. Gilks, D. Bowtell, E. Høgdall, F. J. Candido dos Reis, H. Steed, I. Campbell, J. Gronwald, J. Benítez, J. Koziak, J. Chang-Claude, K. Moysich, L. Kelemen, L. Cook, M. Goodman, M. García, P. Fasching, S. Kommoss, S. Deen, S. K. Kjaer, U. Menon, J. Brenton, P. Pharoah, G. Chenevix-Trench, D. Huntsman, S. Winham, M. Köbel, S. Ramus   +98 more
semanticscholar   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source