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Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer
Frontiers in Immunology, 2023 IntroductionTumor-infiltrating T lymphocytes in the tumor microenvironment are critical factors influencing the prognosis and chemotherapy outcomes. As a Chinese herbal medicine, Marsdenia tenacissima extract (MTE) has been widely used to treat cancer in Ben Yi, Ben Yi, Shuai Zhang, Suying Yan, Suying Yan, Yanfei Liu, Yanfei Liu, Zhiqiang Feng, Zhiqiang Feng, Tianhao Chu, Tianhao Chu, Jun Liu, Wei Wang, Jun Xue, Chunze Zhang, Yijia Wang +15 moredoaj +1 more sourcePitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
npj Breast Cancer, 2020 Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment.Z. Kos, Elvire Roblin, Rim S. Kim, S. Michiels, B. Gallas, Weijie Chen, K. K. van de Vijver, S. Goel, S. Adams, S. Demaria, G. Viale, T. Nielsen, S. Badve, W. Symmans, C. Sotiriou, D. Rimm, S. Hewitt, C. Denkert, S. Loibl, S. Luen, J. Bartlett, P. Savas, G. Pruneri, D. Dillon, M. Cheang, A. Tutt, Jacqueline A. Hall, M. Kok, H. Horlings, A. Madabhushi, J. van der Laak, F. Ciompi, A. Laenkholm, E. Bellolio, T. Gruosso, S. Fox, J. Araya, G. Floris, J. Hudeček, L. Voorwerk, Andrew H. Beck, J. Kerner, D. Larsimont, S. Declercq, G. G. Van den Eynden, L. Pusztai, A. Ehinger, Wentao Yang, K. AbdulJabbar, Yinyin Yuan, Rajendra Singh, C. Hiley, Maise Al Bakir, A. Lazar, S. Naber, S. Wienert, Miluska Castillo, G. Curigliano, M. Dieci, F. André, C. Swanton, J. Reis-Filho, J. Sparano, E. Balslev, I. Chen, E. Stovgaard, K. Pogue-Geile, K. Blenman, F. Penault-Llorca, S. Schnitt, S. Lakhani, A. Vincent-Salomon, F. Rojo, J. Braybrooke, M. Hanna, M. T. Soler-Monsó, D. Bethmann, C. Castañeda, K. Willard-Gallo, Ashish Sharma, H. Lien, S. Fineberg, J. Thagaard, L. Comerma, Paula I. Gonzalez-Ericsson, E. Brogi, S. Loi, J. Saltz, Frederick Klaushen, L. Cooper, M. Amgad, D. Moore, R. Salgado, A. A. I. A. A. A. A. A. A. M. A. Hyytiäinen Hida Thompson Lefevre Gown Lo Sapino Mo, Aini Hyytiäinen, A. Hida, A. Thompson, A. Lefevre, A. Gown, Amy A. Lo, A. Sapino, Andre Moreira, A. Richardson, A. Vingiani, A. Bellizzi, Á. Guerrero, A. Grigoriadis, A. Garrido-Castro, A. Cimino-Mathews, A. Srinivasan, B. Ács, Baljit Singh, B. Calhoun, Benjamin Haibe-Kans, B. Solomon, B. Thapa, B. Nelson, Carmen Ballesteroes-Merino, C. Criscitiello, Carolien Boeckx, C. Colpaert, C. Quinn, C. Chennubhotla, C. Solinas, D. Drubay, D. Sabanathan, D. Peeters, D. Zardavas, D. Höflmayer, Douglas B. Johnson, E. Thompson, E. Perez, E. Elgabry, E. Blackley, Emily S. Reisenbichler, E. Chmielik, F. Gaire, F. Lu, Farid Azmoudeh-Ardalan, F. Peale, F. Hirsch, Gabriela Acosta-Haab, G. Farshid, G. Broeckx, H. Koeppen, H. R. Haynes, H. McArthur, H. Joensuu, H. Olofsson, I. Cree, I. Nederlof, I. Frahm, I. Brčić, Jack Junjie Chan, James Ziai, J. Brock, Jelle Weseling, J. Giltnane, J. Lemonnier, J. Zha, J. Ribeiro, J. Lennerz, J. Carter, J. Hartman, J. Hainfellner, J. Le Quesne, J. Juco, J. G. van den Berg, Joselyn Sanchez, J. Cucherousset, J. Adam, J. Balko, K. Saeger, K. Siziopikou, K. Sikorska, K. Weber, K. Steele, K. Emancipator, K. El Bairi, K. Allison, Konstanty Korski, L. Buisseret, Leming Shi, L. Kooreman, L. Molinero, M. V. Estrada, M. van Seijen, M. Lacroix-Triki, Manu Sebastian, M. Balancin, M. Mathieu, M. J. van de Vijver, M. Rebelatto, M. Piccart, M. Goetz, M. Preusser, M. Khojasteh, M. Sanders, M. Regan, Michael Barnes, M. Christie, M. Misialek, M. Ignatiadis, M. de Maaker, M. V. van Bockstal, N. Harbeck, N. Tung, Nele Laudus, N. Sirtaine, N. Burchardi, N. Ternès, N. Radosevic-Robin, O. Gluz, O. Grimm, P. Nuciforo, P. Jank, Pawan Kirtani, P. Watson, Peter Jelinic, P. Francis, P. Russell, R. Pierce, R. Hills, R. Leon-Ferre, R. De Wind, R. Shui, S. Leung, S. Tabbarah, Sandra C. Souza, S. O'toole, S. Swain, S. Dudgeon, S. Willis, S. Ely, S. Bedri, Sheeba Irshad, Shiwei Liu, S. Hendry, S. Bianchi, S. Bragança, S. Paik, Sua Luz, T. Gevaert, Timothy d’Alfons, T. John, Tomohagu Sugie, U. Kurkure, V. Bossuyt, V. Manem, Vincente Peg Cámaea, W. Tong, W. Tran, Yihong Wang, Y. Allory, Z. Husain, Z. Bago-Horvath +255 moresemanticscholar +1 more sourceReport on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
npj Breast Cancer, 2020 Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors.M. Amgad, E. Stovgaard, E. Balslev, J. Thagaard, Weijie Chen, S. Dudgeon, Ashish Sharma, J. Kerner, C. Denkert, Yinyin Yuan, K. AbdulJabbar, S. Wienert, P. Savas, L. Voorwerk, Andrew H. Beck, A. Madabhushi, J. Hartman, Manu Sebastian, H. Horlings, J. Hudeček, F. Ciompi, D. Moore, Rajendra Singh, Elvire Roblin, M. Balancin, M. Mathieu, J. Lennerz, Pawan Kirtani, I. Chen, J. Braybrooke, G. Pruneri, S. Demaria, S. Adams, S. Schnitt, S. Lakhani, F. Rojo, L. Comerma, S. Badve, M. Khojasteh, W. Symmans, C. Sotiriou, Paula I. Gonzalez-Ericsson, K. Pogue-Geile, Rim S. Kim, D. Rimm, G. Viale, S. Hewitt, J. Bartlett, F. Penault-Llorca, S. Goel, H. Lien, S. Loibl, Z. Kos, S. Loi, M. Hanna, S. Michiels, M. Kok, T. Nielsen, A. Lazar, Z. Bago-Horvath, L. Kooreman, J. van der Laak, J. Saltz, B. Gallas, U. Kurkure, Michael Barnes, R. Salgado, L. Cooper, A. A. I. A. A. A. A. A. A. M. A. Hyytiäinen Hida Thompson Lefevre Gown Lo Sapino Mo, Aini Hyytiäinen, A. Hida, A. Thompson, A. Lefevre, A. Gown, Amy A. Lo, A. Sapino, Andre Moreira, A. Richardson, A. Vingiani, A. Bellizzi, A. Tutt, A. Guerrero-Zotano, A. Grigoriadis, A. Ehinger, A.C. Garrido-Castro, A. Vincent-Salomon, A. Laenkholm, A. Cimino-Mathews, A. Srinivasan, B. Ács, Baljit Singh, B. Calhoun, Benjamin Haibe-Kans, B. Solomon, B. Thapa, B. Nelson, C. Castañeda, Carmen Ballesteroes-Merino, C. Criscitiello, Carolien Boeckx, C. Colpaert, C. Quinn, C. Chennubhotla, C. Swanton, C. Solinas, C. Hiley, D. Drubay, D. Bethmann, D. Dillon, D. Larsimont, D. Sabanathan, D. Peeters, D. Zardavas, D. Höflmayer, Douglas B. Johnson, E. Thompson, E. Brogi, E. Perez, E. Elgabry, E. Blackley, Emily S. Reisenbichler, E. Bellolio, E. Chmielik, F. Gaire, F. André, F. Lu, Farid Azmoudeh-Ardalan, Forbius Tina Gruosso, F. Peale, F. Hirsch, Frederick Klaushen, Gabriela Acosta-Haab, G. Farshid, G. G. Van den Eynden, G. Curigliano, G. Floris, G. Broeckx, H. Koeppen, H. R. Haynes, H. McArthur, H. Joensuu, H. Olofsson, I. Cree, I. Nederlof, I. Frahm, I. Brčić, Jack Junjie Chan, Jacqueline A. Hall, James Ziai, J. Brock, J. Wesseling, J. Giltnane, J. Lemonnier, J. Zha, Joana M. Ribeiro, J. Carter, J. Hainfellner, J. L. Quesne, J. Juco, J. Reis-Filho, J. G. van den Berg, Joselyn Sanchez, J. Sparano, J. Cucherousset, J. Araya, J. Adam, J. Balko, K. Saeger, K. Siziopikou, K. Willard-Gallo, K. Sikorska, K. Weber, K. Steele, K. Emancipator, K. El Bairi, K. Blenman, K. Allison, K. K. van de Vijver, Konstanty Korski, L. Pusztai, L. Buisseret, Leming Shi, L. Shi-wei, L. Molinero, M. V. Estrada, M. van Seijen, M. Lacroix-Triki, M. Cheang, Maise Al Bakir, M. J. van de Vijver, M. Dieci, M. Rebelatto, M. Piccart, M. Goetz, M. Preusser, M. Sanders, M. Regan, M. Christie, M. Misialek, M. Ignatiadis, M. de Maaker, M. V. van Bockstal, Miluska Castillo, N. Harbeck, N. Tung, Nele Laudus, N. Sirtaine, N. Burchardi, N. Ternès, N. Radosevic-Robin, O. Gluz, O. Grimm, P. Nuciforo, P. Jank, P. Jelinic, P. Watson, P. Francis, P. Russell, R. Pierce, R. Hills, R. Leon-Ferre, R. De Wind, R. Shui, S. Declercq, S. Leung, S. Tabbarah, Sandra C. Souza, S. O'toole, S. Swain, S. Willis, S. Ely, Seong-Rim Kim, S. Bedri, Sheeba Irshad, Shiwei Liu, S. Hendry, S. Bianchi, S. Bragança, S. Paik, S. Fox, S. Luen, S. Naber, Sua Luz, S. Fineberg, T. Soler, T. Gevaert, Timothy d’Alfons, T. John, Tomohagu Sugie, V. Bossuyt, V. Manem, Vincente Peg Cámaea, W. Tong, Wentao Yang, W. Tran, Yihong Wang, Y. Allory, Z. Husain +257 moresemanticscholar +1 more sourceTumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Journal of Clinical Oncology, 2015 PURPOSE
Modulation of immunologic interactions in cancer tissue is a promising therapeutic strategy. To investigate the immunogenicity of human epidermal growth factor receptor 2 (HER2) -positive and triple-negative (TN) breast cancers (BCs), we ...C. Denkert, G. von Minckwitz, J. C. Brase, B. Sinn, S. Gade, R. Kronenwett, B. Pfitzner, C. Salat, S. Loi, W. Schmitt, C. Schem, K. Fisch, S. Darb-Esfahani, K. Mehta, C. Sotiriou, S. Wienert, P. Klare, F. André, F. Klauschen, J. Blohmer, K. Krappmann, Marcus Schmidt, H. Tesch, S. Kümmel, P. Sinn, C. Jackisch, M. Dietel, T. Reimer, M. Untch, S. Loibl +29 moresemanticscholar +1 more sourceTumor-infiltrating T lymphocytes: friends or foes? [PDF]
Laboratory Investigation, 2006 The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been a longstanding topic of debate. In cases where TILs have improved patient outcome, T lymphocytes are recognized as the main effectors of antitumor immune responses. However, recent studies have revealed that a subset of CD4(+) T cells, referred to as CD4(+)CD25(+) regulatory ...Ping Yu, Yang Xin Fuopenaire +2 more sourcesCTL Attenuation Regulated by PS1 in Cancer-Associated Fibroblast
Frontiers in Immunology, 2020 Objective: Cancer-associated fibroblasts (CAFs) were associated with tumor progression in the tumor microenvironment (TME). However, their immunosuppressive roles in protecting cancer cells from the attack by cytotoxic T lymphocytes (CTLs) are not fully ...Hongyu Zhang, Rong Jiang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Yanzheng Gu, Yanzheng Gu, Fengqing Fu, Fengqing Fu, Fengqing Fu, Yu Shen, Yu Shen, Yu Shen, Guangbo Zhang, Guangbo Zhang, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Youguo Chen, Fangrong Shen +23 moredoaj +1 more source