Results 61 to 70 of about 267,145 (352)

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe

Advances in Anatomic Pathology, 2017
Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types.
S. Hendry, R. Salgado, T. Gevaert, P. Russell, T. John, T. John, B. Thapa, M. Christie, K. V. D. Vijver, M. V. Estrada, Paula I. Gonzalez-Ericsson, M. Sanders, B. Solomon, C. Solinas, G. V. D. Eynden, Y. Allory, Y. Allory, M. Preusser, J. Hainfellner, G. Pruneri, A. Vingiani, S. Demaria, F. Symmans, P. Nuciforo, L. Comerma, E. Thompson, S. Lakhani, S. Lakhani, Seong-Rim Kim, S. Schnitt, C. Colpaert, C. Sotiriou, S. Scherer, M. Ignatiadis, S. Badve, R. Pierce, G. Viale, N. Sirtaine, F. Penault-Llorca, Tomohagu Sugie, S. Fineberg, S. Paik, A. Srinivasan, A. Richardson, Yihong Wang, Yihong Wang, E. Chmielik, J. Brock, Douglas B. Johnson, J. Balko, S. Wienert, V. Bossuyt, S. Michiels, N. Ternès, N. Burchardi, S. Luen, S. Luen, P. Savas, P. Savas, F. Klauschen, P. Watson, B. Nelson, B. Nelson, C. Criscitiello, S. O'toole, D. Larsimont, R. Wind, G. Curigliano, F. André, M. Lacroix-Triki, Mark van de Vijver, F. Rojo, G. Floris, S. Bedri, J. Sparano, D. Rimm, T. Nielsen, Z. Kos, S. Hewitt, Baljit Singh, G. Farshid, S. Loibl, K. Allison, N. Tung, S. Adams, K. Willard-Gallo, H. Horlings, L. Gandhi, L. Gandhi, Andre Moreira, F. Hirsch, M. Dieci, M. Urbanowicz, I. Brčić, Konstanty Korski, F. Gaire, H. Koeppen, A. Lo, A. Lo, J. Giltnane, M. Rebelatto, K. Steele, J. Zha, K. Emancipator, J. Juco, C. Denkert, J. Reis-Filho, S. Loi, S. Fox   +108 more
semanticscholar   +1 more source

Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes [PDF]

Science Translational Medicine, 2013
A digital DNA-based assay demonstrates an association between higher TIL counts and improved survival among women with ovarian cancer.
Kathy O'Briant, Muneesh Tewari, Nolan G. Ericson, Jamie Guenthoer, Jason H. Bielas, Jason H. Bielas, Harlan Robins, Charles W. Drescher   +7 more
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study

Middle East Journal of Cancer, 2017
Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor
Alireza Ghanadan, Amir-Hoshang Ehsani, Ali-Mohammad Farahmand, Mojtaba Mirzaei   +3 more
doaj  

Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.

Journal of Clinical Oncology, 2014
PURPOSE Recent studies suggest that tumor-infiltrating lymphocytes (TILs) are associated with disease-free (DFS) and overall survival (OS) in operable triple-negative breast cancer (TNBC).
S. Adams, R. Gray, S. Demaria, L. Goldstein, E. Perez, L. Shulman, S. Martino, Molin Wang, V. Jones, T. Saphner, A. Wolff, W. Wood, N. Davidson, G. Sledge, J. Sparano, S. Badve   +15 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer

Human Vaccines & Immunotherapeutics, 2022
Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive
Yahui Zhu, Jing Zhou, Lijing Zhu, Wenjing Hu, Baorui Liu, Li Xie   +5 more
doaj   +1 more source

Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis

BMC Cancer, 2019
The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC).
G. Gao, Zi-Han Wang, X. Qu, Zhongtao Zhang   +3 more
semanticscholar   +1 more source