Results 81 to 90 of about 87,711 (271)

Rare incidence of tumor lysis syndrome in metastatic prostate cancer following treatment with docetaxel

, 2017
Tumor lysis syndrome is a serious and sometimes lethal complication of cancer treatment that is comprised of a set of metabolic disturbances along with clinical manifestations.
Seema Varma, Sharonlin Bhardwaj
core   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Early Recognition and Management of Tumor Lysis Syndrome; An Oncologic Emergency

, 2022
Tumor lysis syndrome is a life-threatening oncologic emergency that often occurs after initiation of cytotoxic therapies or less frequently spontaneously.
Randiak, Leah Wahito
core  

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Tumor Lysis Syndrome in Childhood

Turkish Journal of Nephrology, 2019
Tumor lysis syndrome (TLS) is a clinical condition that results from rapid destruction of the tumor cells and it is associated with life-threatening metabolic abnormalities. These metabolic abnormalities are hyperuricemia, hyperkalemia, hyperphosphatemia
Selçuk YÜKSEL, Mesiha EKİM, Fatoş YALÇINKAYA   +2 more
doaj  

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Tumor Lysis Syndrome in a Retroperitoneal Sarcoma

Journal of Investigative Medicine High Impact Case Reports, 2014
In the present case, a 49-year-old white female presented to the clinic with a 2-month history of nausea, vomiting, and right upper quadrant pain. On examination a 3-cm mass on the right anterior scalene muscle was noted.
Yousef Zakharia MD, Joshua Mansour MD, Srinivasa Vasireddi MD, Kais Zakharia MD, Eduard Fatakhov MD, Christopher Koch, Borys Hrinczenko MD   +6 more
doaj   +1 more source

Tumor lysis syndrome associated with docetaxel and carboplatin in a case with recurrent endometrial cancer

Gynecologic Oncology Reports, 2018
Tumor lysis syndrome (TLS) is an oncological life-threatening complication characterized by hyperuricemia, hyperphosphatemia, and hyperkalemia, which can lead to acute renal failure, cardiac arrhythmias, cardiac arrest and seizures.
Tomomichi Ito, Tsuyoshi Ohta, Megumi Narumi, Hirotsugu Sakaki, Manabu Seino, Takeshi Sudo, Satoru Nagase   +6 more
doaj   +1 more source

Effective prevention and management of tumor lysis syndrome: the important contributions of oncology nurses

, 2014
OBJECTIVES: At present there is no published guideline that describes the corresponding nursing interventions for the prevention and management of tumor lysis syndrome.
Li, H
core   +1 more source