Results 261 to 270 of about 664,473 (309)

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Mechanisms of immunotherapy in cutaneous squamous cell carcinoma in the tumor microenvironment. [PDF]

Front Immunol
Dong Q, Zhang Z, Li S, Liang L.
europepmc   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Circadian rhythms as a modulator of gut microbiota-tumor microenvironment crosstalk. [PDF]

Cell Mol Life Sci
Xu Q, Lin A, Jiang A, Chen L, Zhu L, Mou W, Liu Z, Zhang J, Cheng Q, Miao K, Luo P.   +10 more
europepmc   +1 more source

Hypoxic tumor microenvironment: Destroyer of natural killer cell function

Yongfei Zhang, Feifei Guo, Yufeng Wang
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Endoplasmic reticulum stress-mediated programmed cell death in the tumor microenvironment. [PDF]

Cell Death Discov
Chai H, Hu Q, Yao S, Ma S, Su W.
europepmc   +1 more source

GJB2 Promotes HCC Progression by Activating Glycolysis Through Cytoplasmic Translocation and Generating a Suppressive Tumor Microenvironment Based on Single Cell RNA Sequencing

Han-Yuan Liu, Xiao Li, Chenwei Zhang, Xiaopei Hao, Yongfang Cao, Yuliang Wang, Hao Zhuang, Na Yu, Tian Huang, Chuan Liu, Hengsong Cao, Zhengqing Lu, Jinhua Song, Li Liu, Hanjin Wang, Zhouxiao Li, Weiwei Tang   +16 more
openalex   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Correction: Pediatric tumor microenvironment: developmental dynamics and therapy resistance. [PDF]

Front Oncol
George NG, Rishi B, Dhanda H, Joseph GT, Swain SK, Kaur M, Kushwaha N, Kamal R, Tanwar P, Zaheer S, Zaman S, Singh A, Siraj F, Misra A.   +13 more
europepmc   +1 more source